Abstract
There has long been a concern that all psychotropics may have adverse cardiac effects including prolongation of the QT interval. The recent expanded use of the atypical antipsychotics has increased these concerns. This is a selective review of the effect of the major classes of psychotropic drugs on the QT interval. The review also includes a review of methadone given the high co-morbidity between major psychiatric disorders and substance use disorders.
Keywords: Acquired LQTS, drug-induced QT syndrome, methadone, psychiatry, psychotropics, QT interval, QT prolongation, sudden cardiac death, cardiometabolic risk, arrhythmogenic, mesoridazine, phenothiazines, hypomagnesemia, epidemiologic, tachyarrhythmias
Current Psychopharmacology
Title: Psychotropics and Methadone in Acquired Long QT Syndrome
Volume: 1
Author(s): Stephan Carlson and Russell Joffe
Affiliation:
Keywords: Acquired LQTS, drug-induced QT syndrome, methadone, psychiatry, psychotropics, QT interval, QT prolongation, sudden cardiac death, cardiometabolic risk, arrhythmogenic, mesoridazine, phenothiazines, hypomagnesemia, epidemiologic, tachyarrhythmias
Abstract: There has long been a concern that all psychotropics may have adverse cardiac effects including prolongation of the QT interval. The recent expanded use of the atypical antipsychotics has increased these concerns. This is a selective review of the effect of the major classes of psychotropic drugs on the QT interval. The review also includes a review of methadone given the high co-morbidity between major psychiatric disorders and substance use disorders.
Export Options
About this article
Cite this article as:
Carlson Stephan and Joffe Russell, Psychotropics and Methadone in Acquired Long QT Syndrome, Current Psychopharmacology 2012; 1 (2) . https://dx.doi.org/10.2174/2211556011201020183
DOI https://dx.doi.org/10.2174/2211556011201020183 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease
Current Drug Metabolism Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD
Current Pharmaceutical Design New Therapies to Modulate Post-Infarction Inflammatory Alterations in the Myocardium: State of the Art and Forthcoming Applications
Current Radiopharmaceuticals Models and Methods in Cardiac Imaging for Metabolism Studies
Current Pharmaceutical Design Ezetimibe; More Than a Low Density Lipoprotein Cholesterol Lowering Drug? An Update After 4 Years
Current Vascular Pharmacology Chemometric Modeling of 5-Phenylthiophenecarboxylic Acid Derivatives as Anti-Rheumatic Agents
Current Computer-Aided Drug Design Bone Disease - Current Knowledge and Future Prospects
Current Genomics COVID-19: An Update on Pathogenesis and Treatment
Current Pharmaceutical Design Consumer Understanding and Use of Health Claims: The Case of Functional Foods
Recent Patents on Food, Nutrition & Agriculture Prevention of Sudden Cardiac Death in Hemodialysis Patients
Cardiovascular & Hematological Disorders-Drug Targets Gender Disparity in Lipid Target Achievements in High and Very High Atherosclerotic Cardiovascular Disease Risk Patients in the Arabian Gulf
Current Vascular Pharmacology Inhibitors of Catechol-O-methyltransferase in the Treatment of Neurological Disorders
Central Nervous System Agents in Medicinal Chemistry Cellular Therapy for Heart Failure
Current Cardiology Reviews Odontogenic Infections in the Etiology of Infective Endocarditis
Cardiovascular & Hematological Disorders-Drug Targets An Up-to-Date Review on Citrus Flavonoids: Chemistry and Benefits in Health and Diseases
Current Pharmaceutical Design 1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology
Current Pharmaceutical Design Methylation Profile of miR-9-1 and miR-9-1/-9-3 as Potential Biomarkers of Diabetic Retinopathy
Current Diabetes Reviews Coagulation Factor Xa Inhibition: Biological Background and Rationale
Current Topics in Medicinal Chemistry Medicinal Chemistry Approaches for Glucokinase Activation to Treat Type 2 Diabetes
Current Medicinal Chemistry S100A1: Structure, Function, and Therapeutic Potential
Current Chemical Biology