Abstract
Cardiac health depends on the heart’s ability to utilize different substrates to support overall oxidative metabolism. To characterize a variety of cardiac diseases, there is an ever-growing demand for an accurate non-invasive approach to evaluating myocardial substrate metabolism. Data obtained from quantitative metabolic imaging modalities add functional information to the anatomic imaging modalities and can aid patient management.
The goal of this review is to emphasize the role of non-invasive imaging techniques (such as PET, SPECT, MR spectroscopy and spectroscopic imaging) to detect the metabolic footprints of heart disease. The advancements of models and methods to estimate kinetic parameters of dynamic processes using data acquired from cardiac imaging modalities is discussed.
Keywords: Positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy, magnetic resonance spectroscopic imaging, cardiac metabolism, metabolic imaging, compartmental models, kinetic models, kinetic parameter estimation and fitting.
Current Pharmaceutical Design
Title:Models and Methods in Cardiac Imaging for Metabolism Studies
Volume: 20 Issue: 39
Author(s): Santarelli M.F., Martini N., Positano P. and Landini L.
Affiliation:
Keywords: Positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy, magnetic resonance spectroscopic imaging, cardiac metabolism, metabolic imaging, compartmental models, kinetic models, kinetic parameter estimation and fitting.
Abstract: Cardiac health depends on the heart’s ability to utilize different substrates to support overall oxidative metabolism. To characterize a variety of cardiac diseases, there is an ever-growing demand for an accurate non-invasive approach to evaluating myocardial substrate metabolism. Data obtained from quantitative metabolic imaging modalities add functional information to the anatomic imaging modalities and can aid patient management.
The goal of this review is to emphasize the role of non-invasive imaging techniques (such as PET, SPECT, MR spectroscopy and spectroscopic imaging) to detect the metabolic footprints of heart disease. The advancements of models and methods to estimate kinetic parameters of dynamic processes using data acquired from cardiac imaging modalities is discussed.
Export Options
About this article
Cite this article as:
M.F. Santarelli, N. Martini, P. Positano and L. Landini, Models and Methods in Cardiac Imaging for Metabolism Studies, Current Pharmaceutical Design 2014; 20 (39) . https://dx.doi.org/10.2174/1381612820666140417114122
DOI https://dx.doi.org/10.2174/1381612820666140417114122 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Genetically Modified Endothelial Progenitor Cells in the Therapy of Cardiovascular Disease and Pulmonary Hypertension
Current Vascular Pharmacology Doxorubicin: The Good, the Bad and the Ugly Effect
Current Medicinal Chemistry Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling
Cardiovascular & Hematological Disorders-Drug Targets Editorial from Editor-in-Chief [Cheyne-Stokes: A Flashback to the 19th Century]
Current Respiratory Medicine Reviews Association Between Hypothyroidism and Takotsubo Cardiomyopathy: Analysis of Nationwide Inpatient Sample Database
Reviews on Recent Clinical Trials Endothelial Microparticles: Mediators or Markers of Endothelial Cell Dysfunction?
Current Hypertension Reviews Therapeutic Angiogenesis by Gene Therapy for Critical Limb Ischemia: Choice of Biological Agent
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Immunoglobulin Therapy, Myocardial Diseases and Atherosclerosis:Recent Experimental and Clinical Studies
Current Cardiology Reviews The Diagnostic and Prognostic Value of Brain Natriuretic Peptide and Aminoterminal (nt)-pro Brain Natriuretic Peptide
Current Pharmaceutical Design GDF11 Attenuated ANG II-Induced Hypertrophic Cardiomyopathy and Expression of ANP, BNP and Beta-MHC Through Down- Regulating CCL11 in Mice
Current Molecular Medicine Strategies for Enhancing Progenitor Cell Mobilization and Function in Diabetes
Current Vascular Pharmacology Aldosteronism in Heart Failure: A Proinflammatory / Fibrogenic Cardiac Phenotype. Search for Biomarkers and Potential Drug Targets
Current Drug Targets Deep Inspiration Breath-hold (DIBH) Technique to Reduce Cardiac Radiation Dose in the Management of Breast Cancer
Current Cancer Therapy Reviews Editorial from Editor-in-Chief: Amniotic Pulmonary Embolism and the Respiratory System: Management Trends and Future Options
Current Respiratory Medicine Reviews An Overview of Bioactive Peptides for in vivo Imaging and Therapy in Human Diseases
Mini-Reviews in Medicinal Chemistry Advanced Therapies For End-Stage Heart Failure
Current Cardiology Reviews Evaluation and Management of Atrial Fibrillation
Cardiovascular & Hematological Disorders-Drug Targets microRNA Regulation as a Therapeutic Strategy for Cardiovascular Disease
Current Drug Targets Enzyme Replacement Therapy in Fabry Disease: Influence on Cardiac Manifestations
Current Medicinal Chemistry Editorial [Hot Topic: Applications of Angiotensin Converting Enzyme Inhibitors and of Angiotensin II Receptor Blockers in Pharmacology and Therapy: An Update (Executive Editor: Agostino Molteni)]
Current Pharmaceutical Design