Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds

Title: Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds

Volume: 5 Issue: 8

Author(s): I. G. De Lade, F. G. Braga, R. M. Grazul, E. S. Coimbra and A. D. Da Silva

Affiliation:

Keywords: D-psicofuranose, 6-mercaptopurine, 2-mercaptopyrimidine, 4-mercaptopyridine, 2-mercaptobenzimidazole

Abstract: We report herein the synthesis of a series of eight novel compounds based on the coupling of 6-mercaptopurine (4), 2-mercaptopyrimidine (5), 4-mercaptopyridine (6) and 2-mercaptobenzimidazole (7) with 6-deoxy-6-iodo-1,2:3,4-di- O-isopropylidene-γ-D-psicofuranose and subsequent deprotection. The compounds were evaluated in vitro for activity against Leishmania amazonensis and L. chagasi promastigotes and for cytotoxic activity against Kb and Vero cells.

Cite this article as:

De Lade G. I., Braga G. F., Grazul M. R., Coimbra S. E. and Da Silva D. A., Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds, Letters in Drug Design & Discovery 2008; 5 (8) . https://dx.doi.org/10.2174/157018008786898554

DOI https://dx.doi.org/10.2174/157018008786898554	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X