Abstract
The emergence of multidrug-resistant (MDR) pathogens and cancers alarms the world for the urgent exploration of new therapeutic drugs to treat the superbugs and cancer patients. Since the ancient time, natural products and/or their derivatives have become continuous sources of leading commercialized pharmacological compounds that are used as antibiotics and antitumor agents. An unexplored source of natural products, lichen, currently has evolved into a propitious source of diverse secondary metabolites with various bio-activities including anticancer and antimicrobial, offering the abundant potentiality for future drugs. Herein, we summarized the progress in the discovery of structurally diverse anticancer compounds (C1-C85) with their plausible mode of action and antimicrobial compounds (M1-M112) from lichen and lichen-derived fungi together with their biodiversity. This review covers natural products discussed in literature from January 1985 to December 2017.
Keywords: Lichen, anticancer and antimicrobial, biodiversity, diverse metabolites, secondary metabolites, lichenized fungi.
Graphical Abstract
Current Organic Chemistry
Title:Diversity of Anticancer and Antimicrobial Compounds from Lichens and Lichen-derived Fungi: A Systematic Review (1985-2017)
Volume: 22 Issue: 25
Author(s): Buddha Bahadur Basnet, Hongwei Liu*, Li Liu and Yerlan Melsuly Suleimen
Affiliation:
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing,China
Keywords: Lichen, anticancer and antimicrobial, biodiversity, diverse metabolites, secondary metabolites, lichenized fungi.
Abstract: The emergence of multidrug-resistant (MDR) pathogens and cancers alarms the world for the urgent exploration of new therapeutic drugs to treat the superbugs and cancer patients. Since the ancient time, natural products and/or their derivatives have become continuous sources of leading commercialized pharmacological compounds that are used as antibiotics and antitumor agents. An unexplored source of natural products, lichen, currently has evolved into a propitious source of diverse secondary metabolites with various bio-activities including anticancer and antimicrobial, offering the abundant potentiality for future drugs. Herein, we summarized the progress in the discovery of structurally diverse anticancer compounds (C1-C85) with their plausible mode of action and antimicrobial compounds (M1-M112) from lichen and lichen-derived fungi together with their biodiversity. This review covers natural products discussed in literature from January 1985 to December 2017.
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Cite this article as:
Basnet Bahadur Buddha , Liu Hongwei *, Liu Li and Suleimen Melsuly Yerlan , Diversity of Anticancer and Antimicrobial Compounds from Lichens and Lichen-derived Fungi: A Systematic Review (1985-2017), Current Organic Chemistry 2018; 22 (25) . https://dx.doi.org/10.2174/1385272822666181109110813
DOI https://dx.doi.org/10.2174/1385272822666181109110813 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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