The Reactions Between HOCl and Differently Saturated Phospholipids: Physiological Relevance, Products and Methods of Evaluation

Title: The Reactions Between HOCl and Differently Saturated Phospholipids: Physiological Relevance, Products and Methods of Evaluation

Volume: 5 Issue: 3

Author(s): Beate Fuchs, Celestina Schober, Grit Richter, Ariane Nimptsch, Rosmarie Suß and Jurgen Schiller

Affiliation:

Keywords: HOCl, Saturated Phospholipids, reactive oxygen species (ROS), mass spectrometric techniques, phosphatidylcholine (PC)

Abstract: Phospholipids (PLs) are important constituents of cellular membranes. HOCl is a reactive oxygen species (ROS) generated under inflammatory conditions and capable of reacting with (a) the head group of PLs and (b) the olefinic groups of their fatty acyl residues under the preferred generation of chloramines and chlorohydrines, respectively. This review discusses these products, their stabilities and in vivo relevance. Additionally, important methods (spectroscopic as well as mass spectrometric techniques) to analyze these products are compared.

Cite this article as:

Fuchs Beate, Schober Celestina, Richter Grit, Nimptsch Ariane, Suß Rosmarie and Schiller Jurgen, The Reactions Between HOCl and Differently Saturated Phospholipids: Physiological Relevance, Products and Methods of Evaluation, Mini-Reviews in Organic Chemistry 2008; 5 (3) . https://dx.doi.org/10.2174/157019308785161648