Abstract
In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.
Keywords: Phenylpyrazoleanilide, IL-15, Prodrug, CIA
Letters in Drug Design & Discovery
Title: Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators
Volume: 5 Issue: 2
Author(s): Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita and Kenji Chiba
Affiliation:
Keywords: Phenylpyrazoleanilide, IL-15, Prodrug, CIA
Abstract: In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.
Export Options
About this article
Cite this article as:
Ushio Hiroyuki, Ishibuchi Seigo, Adachi Kunitomo, Oshita Kouichi and Chiba Kenji, Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators, Letters in Drug Design & Discovery 2008; 5 (2) . https://dx.doi.org/10.2174/157018008783928427
DOI https://dx.doi.org/10.2174/157018008783928427 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Insulin Secretagogues, Sulfonylurea Receptors and KATP Channels
Current Pharmaceutical Design Signalling Cascades in Ventilator-Induced Lung Injury and Their Implications for Patient Therapies
Current Signal Transduction Therapy Effects and Role of Multikinase Inhibitors in Thyroid Cancer
Current Pharmaceutical Design Effects of Specific Cyclooxygenase-2 Inhibitors on Carcinogenesis
Medicinal Chemistry Reviews - Online (Discontinued) Therapeutics Interventions with Anti-Inflammatory Creams in Post Radiation Acute Skin Reactions: A Systematic Review of Most Important Clinical Trials
Recent Patents on Inflammation & Allergy Drug Discovery Potential Drugs Targeting Microglia: Current Knowledge and Future Prospects
CNS & Neurological Disorders - Drug Targets Oxidative Modification of Lipoproteins: Mechanisms, Role in Inflammation and Potential Clinical Applications in Cardiovascular Disease
Current Pharmaceutical Design Human Model Neurons in Studies of Brain Cell Damage and Neural Repair
Current Molecular Medicine An Oligodeoxynucleotide with CCT Repeats Restrains CpG ODN-Induced TLR9 Trafficking
Current Pharmaceutical Biotechnology Therapeutically Targeting MicroRNAs in Liver Cancer
Current Pharmaceutical Design Neurokinin Peptides and Neurokinin Receptors as Potential Therapeutic Intervention Targets of Basal Ganglia in the Prevention and Treatment of Parkinsons Disease
Current Drug Targets Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy
Current Medicinal Chemistry Inhaled Corticosteroids and Pneumonia in Chronic Obstructive Pulmonary Disease
Current Respiratory Medicine Reviews Pathogenesis of Acute Kidney Injury During Sepsis
Current Drug Targets Cytokine Gene Transfer into Dendritic Cells for Cancer Treatment
Current Gene Therapy New Drug Targets for Hepatitis C and Other Flaviviridae Viruses
Infectious Disorders - Drug Targets Prebiotic Carbohydrates for Therapeutics
Endocrine, Metabolic & Immune Disorders - Drug Targets Management of Complicated Pneumonia in Childhood: A Review of Recent Literature
Reviews on Recent Clinical Trials Benfotiamine Reduces Dendritic Cell Inflammatory Potency
Endocrine, Metabolic & Immune Disorders - Drug Targets Revision of Immunopathogenesis and Laboratory Interpretation for Food Allergy in Atopic Dermatitis
Inflammation & Allergy - Drug Targets (Discontinued)