Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk

Title: Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk

Volume: 8 Issue: 6

Author(s): Pascual DeSantis, Trey Coleman, Stephan Schiekofer, Peter P. Nawroth, Paul Schlimmer and Jochen G. Schneider

Affiliation:

Keywords: HDL metabolism, atherosclerosis, inflammation

Abstract: Endothelial Lipase (EL) is a newly identified member of the triacylglycerol lipase family. Recent studies suggested that EL may be an important determinant of HDL-metabolism and inflammation acting at the level of the vessel wall. The aim of this review is to summarize important facts derived from experimental approaches and from epidemiologic human studies to provide a comprehensive view on the role of EL in inflammation and atherogenesis as well as target for potential pharmaceutical interventions.

Cite this article as:

DeSantis Pascual, Coleman Trey, Schiekofer Stephan, Nawroth P. Peter, Schlimmer Paul and Schneider G. Jochen, Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk, Mini-Reviews in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/138955708784534427