Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy

Title: Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy

Volume: 8 Issue: 6

Author(s): Chiara Riganti, Elisabetta Aldieri, Sophie Doublier, Amalia Bosia and Dario Ghigo

Affiliation:

Keywords: Rho GTPases, cancer, isoprenylation, statins, chemotherapy

Abstract: Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.

Cite this article as:

Riganti Chiara, Aldieri Elisabetta, Doublier Sophie, Bosia Amalia and Ghigo Dario, Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy, Mini-Reviews in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/138955708784534436