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Letters in Functional Foods

Editor-in-Chief

ISSN (Print): 2666-9390
ISSN (Online): 2666-9404

Review Article

From Scraps to Solutions: Harnessing the Potential of Vegetable and Fruit Waste in Pharmaceutical Formulations

Author(s): Vishnu Mittal and Anjali Sharma*

Volume 1, 2024

Published on: 23 January, 2024

Article ID: e230124225963 Pages: 17

DOI: 10.2174/0126669390271001231122051310

Price: $65

Abstract

Background: Food waste is a major worldwide problem due to the increasing population and imbalances in supply chains. Waste from fruits and vegetables are a substantial proportion of the overall food waste generated, accounting for approximately 42% of the waste produced. Methane, a strong greenhouse gas with a significant potential for global warming, is produced when these waste products are typically dumped in landfills.

Objectives: The study's goal is to present a thorough overview of the most recent findings and developments in the use of vegetable and fruit waste for creating therapeutic formulations. Recognizing the opportunities and challenges in this developing area of study, as well as the promise that vegetable and fruit waste contains for the creation of environmentally friendly and economically advantageous pharmaceutical formulations.

Methods: A comprehensive review of existing literature on the utilization of vegetable and fruit waste in pharmaceutical formulations was conducted. The review included studies on the chemical composition and bioactive compounds present in various types of vegetable and fruit waste, their extraction methods, and their potential applications in pharmaceutical formulations. Additionally, current waste management practices and challenges associated with waste disposal were also analyzed.

Conclusion: The review highlights the significant potential of vegetable and fruit waste in the development of pharmaceutical formulations. Fruit and vegetable waste offer a wide range of bioactive compounds, such as antioxidants, antimicrobials, and antiinflammatory agents, which could be utilized in drug formulation. Moreover, this approach can promote environmental sustainability by reducing waste generation and enhancing waste utilization. Further research and development efforts should focus on optimizing extraction methods, evaluating the efficacy and safety of wastederived compounds, and addressing regulatory requirements for integrating vegetable and fruit waste into pharmaceutical products. Harnessing the potential of vegetable and fruit waste in pharmaceutical formulations can lead to sustainable advancements in the pharmaceutical industry while addressing environmental concerns.

[1]
Fierascu RC, Sieniawska E, Ortan A, Fierascu I, Xiao J. Fruits by-products – a source of valuable active principles. A short review. Front Bioeng Biotechnol 2020; 8: 319.
[http://dx.doi.org/10.3389/fbioe.2020.00319] [PMID: 32351951]
[2]
Lucarini M, Durazzo A, Bernini R, et al. Fruit wastes as a valuable source of value-added compounds: A collaborative perspective. Molecules 2021; 26(21): 6338.
[http://dx.doi.org/10.3390/molecules26216338] [PMID: 34770747]
[3]
Esparza I, Jiménez-Moreno N, Bimbela F, Ancín-Azpilicueta C, Gandía LM. Fruit and vegetable waste management: Conventional and emerging approaches. J Environ Manage 2020; 265: 110510.
[http://dx.doi.org/10.1016/j.jenvman.2020.110510] [PMID: 32275240]
[4]
Ganesh KS, Sridhar A, Vishali S. Utilization of fruit and vegetable waste to produce value-added products: Conventional utilization and emerging opportunities-A review. Chemosphere 2022; 287(Pt 3): 132221.
[http://dx.doi.org/10.1016/j.chemosphere.2021.132221] [PMID: 34560492]
[5]
Gajda I, Greenman J, Santoro C, et al. Multi‐functional microbial fuel cells for power, treatment and electro‐osmotic purification of urine. J Chem Technol Biotechnol 2019; 94(7): 2098-106.
[http://dx.doi.org/10.1002/jctb.5792] [PMID: 31423040]
[6]
Shelton AM, Sarwer SH, Hossain MJ, Brookes G, Paranjape V. Impact of Bt brinjal cultivation in the market value chain in five districts of Bangladesh. Front Bioeng Biotechnol 2020; 8: 498.
[http://dx.doi.org/10.3389/fbioe.2020.00498] [PMID: 32528942]
[7]
Kumari D, John S. Health risk assessment of pesticide residues in fruits and vegetables from farms and markets of Western Indian Himalayan region. Chemosphere 2019; 224: 162-7.
[http://dx.doi.org/10.1016/j.chemosphere.2019.02.091] [PMID: 30822723]
[8]
Sagar NA, Pareek S, Sharma S, Yahia EM, Lobo MG. Fruit and vegetable waste: Bioactive compounds, their extraction, and possible utilization. Compr Rev Food Sci Food Saf 2018; 17(3): 512-31.
[http://dx.doi.org/10.1111/1541-4337.12330] [PMID: 33350136]
[9]
Rodríguez García SL, Raghavan V. Green extraction techniques from fruit and vegetable waste to obtain bioactive compounds—A review. Crit Rev Food Sci Nutr 2022; 62(23): 6446-66.
[http://dx.doi.org/10.1080/10408398.2021.1901651] [PMID: 33792417]
[10]
Nirmal NP, Khanashyam AC, Mundanat AS, et al. Valorization of fruit waste for bioactive compounds and their applications in the food industry. Foods 2023; 12(3): 556.
[http://dx.doi.org/10.3390/foods12030556] [PMID: 36766085]
[11]
Coman V, Teleky BE, Mitrea L, et al. Bioactive potential of fruit and vegetable wastes. Adv Food Nutr Res 2020; 91: 157-225.
[http://dx.doi.org/10.1016/bs.afnr.2019.07.001] [PMID: 32035596]
[12]
Kumar H, Bhardwaj K, Sharma R, et al. Fruit and vegetable peels: Utilization of high value horticultural waste in novel industrial applications. Molecules 2020; 25(12): 2812.
[http://dx.doi.org/10.3390/molecules25122812] [PMID: 32570836]
[13]
Pem D, Jeewon R. Fruit and vegetable intake: Benefits and progress of nutrition education interventions- narrative review article. Iran J Public Health 2015; 44(10): 1309-21.
[PMID: 26576343]
[14]
Hussain H, Mamadalieva NZ, Hussain A, et al. Fruit peels: Food waste as a valuable source of bioactive natural products for drug discovery. Curr Issues Mol Biol 2022; 44(5): 1960-94.
[http://dx.doi.org/10.3390/cimb44050134] [PMID: 35678663]
[15]
Bhardwaj K, Najda A, Sharma R, et al. Fruit and vegetable peel-enriched functional foods: Potential avenues and health perspectives. Evid Based Complement Alternat Med 2022; 2022: 1-14.
[http://dx.doi.org/10.1155/2022/8543881] [PMID: 35832524]
[16]
Deng GF, Shen C, Xu XR, et al. Potential of fruit wastes as natural resources of bioactive compounds. Int J Mol Sci 2012; 13(7): 8308-23.
[http://dx.doi.org/10.3390/ijms13078308] [PMID: 22942704]
[17]
Altemimi A, Lakhssassi N, Baharlouei A, Watson D, Lightfoot D. Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts. Plants 2017; 6(4): 42.
[http://dx.doi.org/10.3390/plants6040042] [PMID: 28937585]
[18]
Sasidharan S, Chen Y, Saravanan D, Sundram KM, Yoga Latha L. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr J Tradit Complement Altern Med 2011; 8(1): 1-10.
[PMID: 22238476]
[19]
Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: A comprehensive review. Chin Med 2018; 13(1): 20.
[http://dx.doi.org/10.1186/s13020-018-0177-x] [PMID: 29692864]
[20]
Hamed I, Jakobsen AN, Lerfall J. Sustainable edible packaging systems based on active compounds from food processing byproducts: A review. Compr Rev Food Sci Food Saf 2022; 21(1): 198-226.
[http://dx.doi.org/10.1111/1541-4337.12870] [PMID: 34907649]
[21]
Francini A, Pintado M, Manganaris GA, Ferrante A. Editorial: Bioactive compounds biosynthesis and metabolism in fruit and vegetables. Front Plant Sci 2020; 11: 129.
[http://dx.doi.org/10.3389/fpls.2020.00129] [PMID: 32140170]
[22]
Yu M, Gouvinhas I, Rocha J, Barros AIRNA. Phytochemical and antioxidant analysis of medicinal and food plants towards bioactive food and pharmaceutical resources. Sci Rep 2021; 11(1): 10041.
[http://dx.doi.org/10.1038/s41598-021-89437-4] [PMID: 33976317]
[23]
Martínez-Inda B, Esparza I, Moler JA, Jiménez-Moreno N, Ancín-Azpilicueta C. Valorization of agri-food waste through the extraction of bioactive molecules. Prediction of their sunscreen action. J Environ Manage 2023; 325(Pt B): 116460.
[24]
ANDRICORY AA. The differences in food waste management of tesco company and albert heijn company. Doctoral dissertation, Universitas Islam Indonesia
[25]
Lombardi A, Fochetti A, Vignolini P, et al. Natural active ingredients for poly (lactic acid)-based materials: State of the art and perspectives. Antioxidants 2022; 11(10): 2074.
[http://dx.doi.org/10.3390/antiox11102074] [PMID: 36290797]
[26]
Saini RK, Prasad P, Lokesh V, et al. Carotenoids: Dietary sources, extraction, encapsulation, bioavailability, and health benefits—a review of recent advancements. Antioxidants 2022; 11(4): 795.
[http://dx.doi.org/10.3390/antiox11040795] [PMID: 35453480]
[27]
Maqbool Z, Khalid W, Atiq HT, et al. Citrus waste as source of bioactive compounds: Extraction and utilization in health and food industry. Molecules 2023; 28(4): 1636.
[http://dx.doi.org/10.3390/molecules28041636] [PMID: 36838623]
[28]
Lyu F, Luiz SF, Azeredo DRP, Cruz AG, Ajlouni S, Ranadheera CS. Apple pomace as a functional and healthy ingredient in food products: A review. Processes 2020; 8(3): 319.
[http://dx.doi.org/10.3390/pr8030319]
[29]
Frum A, Dobrea CM, Rus LL, et al. Valorization of grape pomace and berries as a new and sustainable dietary supplement: Development, characterization, and antioxidant activity testing. Nutrients 2022; 14(15): 3065.
[http://dx.doi.org/10.3390/nu14153065] [PMID: 35893915]
[30]
Szabo K, Diaconeasa Z, Cătoi AF, Vodnar DC. Screening of ten tomato varieties processing waste for bioactive components and their related antioxidant and antimicrobial activities. Antioxidants 2019; 8(8): 292.
[http://dx.doi.org/10.3390/antiox8080292] [PMID: 31398838]
[31]
Gu I, Balogun O, Brownmiller C, Kang HW, Lee SO. Bioavailability of citrulline in watermelon flesh, rind, and skin using a human intestinal epithelial caco-2 cell model. Appl Sci 2023; 13(8): 4882.
[http://dx.doi.org/10.3390/app13084882]
[32]
Varilla C, Marcone M, Paiva L, Baptista J. Bromelain, a group of pineapple proteolytic complex enzymes (Ananas comosus) and their possible therapeutic and clinical effects. A Summary. Foods 2021; 10(10): 2249.
[http://dx.doi.org/10.3390/foods10102249] [PMID: 34681298]
[33]
Hikal WM, Said-Al Ahl HAH, Bratovcic A, et al. Banana peels: A waste treasure for human being. Evid Based Complement Alternat Med 2022; 2022: 1-9.
[http://dx.doi.org/10.1155/2022/7616452] [PMID: 35600962]
[34]
Ahmad T, Cawood M, Iqbal Q, et al. Phytochemicals in daucus carota and their health benefits—review article. Foods 2019; 8(9): 424.
[http://dx.doi.org/10.3390/foods8090424] [PMID: 31546950]
[35]
Marefati N, Ghorani V, Shakeri F, et al. A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents. Pharm Biol 2021; 59(1): 285-300.
[http://dx.doi.org/10.1080/13880209.2021.1874028] [PMID: 33645419]
[36]
Hussain A, Kausar T, Sehar S, et al. Utilization of pumpkin, pumpkin powders, extracts, isolates, purified bioactives and pumpkin based functional food products; a key strategy to improve health in current post COVID 19 period; an updated review. Appl Food Res 2022; 2(2): 100241.
[37]
Angulo-López JE, Flores-Gallegos AC, Ascacio-Valdes JA, et al. Antioxidant dietary fiber sourced from agroindustrial byproducts and its applications. Foods 2022; 12(1): 159.
[http://dx.doi.org/10.3390/foods12010159] [PMID: 36613377]
[38]
Selim S, Albqmi M, Al-Sanea MM, et al. Valorizing the usage of olive leaves, bioactive compounds, biological activities, and food applications: A comprehensive review. Front Nutr 2022; 9: 1008349.
[http://dx.doi.org/10.3389/fnut.2022.1008349] [PMID: 36424930]
[39]
Bangar SP, Dunno K, Dhull SB, et al. Avocado seed discoveries: Chemical composition, biological properties, and industrial food applications. Food Chem X 2022; 16: 100507.
[http://dx.doi.org/10.1016/j.fochx.2022.100507] [PMID: 36573158]
[40]
Micheletti LI, Érica MJ, Luiza FVA, et al. Beet (Beta vulgaris L.) stalk and leaf supplementation changes the glucose homeostasis and inflammatory markers in the liver of mice exposed to a high-fat diet. Food Chemistry: Molecular Sciences 2021; 2: 100018.
[http://dx.doi.org/10.1016/j.fochms.2021.100018] [PMID: 35415624]
[41]
Salas-Arias K, Irías-Mata A, Sánchez-Kopper A, et al. Strawberry Fragaria x ananassa cv. festival: A polyphenol-based phytochemical characterization in fruit and leaf extracts. Molecules 2023; 28(4): 1865.
[http://dx.doi.org/10.3390/molecules28041865] [PMID: 36838852]
[42]
Mukherjee PK, Nema NK, Maity N, Sarkar BK. Phytochemical and therapeutic potential of cucumber. Fitoterapia 2013; 84: 227-36.
[http://dx.doi.org/10.1016/j.fitote.2012.10.003] [PMID: 23098877]
[43]
Viera W, Shinohara T, Samaniego I, et al. Phytochemical composition and antioxidant activity of Passiflora spp. germplasm grown in ecuador. Plants 2022; 11(3): 328.
[http://dx.doi.org/10.3390/plants11030328] [PMID: 35161309]
[44]
Mo Y, Ma J, Gao W, et al. Pomegranate peel as a source of bioactive compounds: A mini review on their physiological functions. Front Nutr 2022; 9: 887113.
[http://dx.doi.org/10.3389/fnut.2022.887113] [PMID: 35757262]
[45]
Kumar M, Tomar M, Amarowicz R, et al. Guava (Psidium guajava L.) leaves: Nutritional composition, phytochemical profile, and health-promoting bioactivities. Foods 2021; 10(4): 752.
[http://dx.doi.org/10.3390/foods10040752] [PMID: 33916183]
[46]
Ranjan A, Ramachandran S, Gupta N, et al. Role of phytochemicals in cancer prevention. Int J Mol Sci 2019; 20(20): 4981.
[http://dx.doi.org/10.3390/ijms20204981] [PMID: 31600949]
[47]
Kalt W, Cassidy A, Howard LR, et al. Recent research on the health benefits of blueberries and their anthocyanins. Adv Nutr 2020; 11(2): 224-36.
[http://dx.doi.org/10.1093/advances/nmz065] [PMID: 31329250]
[48]
Kim YM, Abas F, Park YS, et al. Bioactivities of phenolic compounds from kiwifruit and persimmon. Molecules 2021; 26(15): 4405.
[http://dx.doi.org/10.3390/molecules26154405] [PMID: 34361562]
[49]
González de Llano D, Moreno-Arribas MV, Bartolomé B. Cranberry polyphenols and prevention against urinary tract infections: Relevant considerations. Molecules 2020; 25(15): 3523.
[http://dx.doi.org/10.3390/molecules25153523] [PMID: 32752183]
[50]
Pavan R, Jain S, Shraddha , Kumar A. Properties and therapeutic application of bromelain: A review. Biotechnol Res Int 2012; 2012: 1-6.
[http://dx.doi.org/10.1155/2012/976203] [PMID: 23304525]
[51]
Park YS, Kim I, Dhungana SK, et al. Quality characteristics and antioxidant potential of lemon (Citrus limon Burm. f.) seed oil extracted by different methods. Front Nutr 2021; 8: 644406.
[http://dx.doi.org/10.3389/fnut.2021.644406] [PMID: 34568400]
[52]
Ağagündüz D, Şahin TÖ, Yılmaz B, Ekenci KD, Duyar Özer Ş, Capasso R. Cruciferous vegetables and their bioactive metabolites: From prevention to novel therapies of colorectal cancer. Evid Based Complement Alternat Med 2022; 2022: 1-20.
[http://dx.doi.org/10.1155/2022/1534083] [PMID: 35449807]
[53]
Kong YR, Jong YX, Balakrishnan M, et al. Beneficial role of Carica papaya extracts and phytochemicals on oxidative stress and related diseases: A mini review. Biology 2021; 10(4): 287.
[http://dx.doi.org/10.3390/biology10040287] [PMID: 33916114]
[54]
Batiha GES, Alqahtani A, Ojo OA, et al. Biological properties, bioactive constituents, and pharmacokinetics of some capsicum spp. and capsaicinoids. Int J Mol Sci 2020; 21(15): 5179.
[http://dx.doi.org/10.3390/ijms21155179] [PMID: 32707790]
[55]
Amini MR, Sheikhhossein F, Talebyan A, Bazshahi E, Djafari F, Hekmatdoost A. Effects of artichoke supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr Res 2022; 11(3): 228-39.
[http://dx.doi.org/10.7762/cnr.2022.11.3.228] [PMID: 35949559]
[56]
Kim H, Castellon-Chicas MJ, Arbizu S, et al. Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions. Molecules 2021; 26(9): 2732.
[http://dx.doi.org/10.3390/molecules26092732] [PMID: 34066494]
[57]
Szymanowska U, Baraniak B. Antioxidant and potentially anti-inflammatory activity of anthocyanin fractions from pomace obtained from enzymatically treated raspberries. Antioxidants 2019; 8(8): 299.
[http://dx.doi.org/10.3390/antiox8080299] [PMID: 31405151]
[58]
Pérez-Gálvez A, Viera I, Roca M. Carotenoids and chlorophylls as antioxidants. Antioxidants 2020; 9(6): 505.
[http://dx.doi.org/10.3390/antiox9060505] [PMID: 32526968]
[59]
Hong SY, Lansky E, Kang SS, Yang M. A review of pears (Pyrus spp.), ancient functional food for modern times. BMC Complement Med Ther 2021; 21(1): 219.
[http://dx.doi.org/10.1186/s12906-021-03392-1] [PMID: 34470625]
[60]
Laveriano-Santos EP, López-Yerena A, Jaime-Rodríguez C, et al. Sweet potato is not simply an abundant food crop: A comprehensive review of its phytochemical constituents, biological activities, and the effects of processing. Antioxidants 2022; 11(9): 1648.
[http://dx.doi.org/10.3390/antiox11091648] [PMID: 36139723]
[61]
Beconcini D, Felice F, Fabiano A, Sarmento B, Zambito Y, Di Stefano R. Antioxidant and anti-inflammatory properties of cherry extract: Nanosystems-based strategies to improve endothelial function and intestinal absorption. Foods 2020; 9(2): 207.
[http://dx.doi.org/10.3390/foods9020207] [PMID: 32079234]
[62]
Manivannan A, Kim JH, Kim DS, Lee ES, Lee HE. Deciphering the nutraceutical potential of raphanus sativus—A comprehensive overview. Nutrients 2019; 11(2): 402.
[http://dx.doi.org/10.3390/nu11020402] [PMID: 30769862]
[63]
Mitra S, Emran TB, Chandran D, et al. Cruciferous vegetables as a treasure of functional foods bioactive compounds: Targeting p53 family in gastrointestinal tract and associated cancers. Front Nutr 2022; 9: 951935.
[http://dx.doi.org/10.3389/fnut.2022.951935] [PMID: 35990357]
[64]
Condurache Lazăr NN, Croitoru C, Enachi E, Bahrim GE, Stănciuc N, Râpeanu G. Eggplant peels as a valuable source of anthocyanins: Extraction, thermal stability and biological activities. Plants 2021; 10(3): 577.
[http://dx.doi.org/10.3390/plants10030577] [PMID: 33803722]
[65]
Akhone MA, Bains A, Tosif MM, Chawla P, Fogarasi M, Fogarasi S. Apricot kernel: Bioactivity, characterization, applications, and health attributes. Foods 2022; 11(15): 2184.
[http://dx.doi.org/10.3390/foods11152184] [PMID: 35892769]
[66]
Kooti W, Daraei N. A review of the antioxidant activity of celery (Apium graveolens L). J Evid Based Complementary Altern Med 2017; 22(4): 1029-34.
[http://dx.doi.org/10.1177/2156587217717415] [PMID: 28701046]
[67]
Mawa S, Husain K, Jantan I. Ficus carica L. (Moraceae): Phytochemistry, traditional uses and biological activities. Evid Based Complement Alternat Med 2013; 2013: 1-8.
[http://dx.doi.org/10.1155/2013/974256] [PMID: 24159359]
[68]
Kobo GK, Kaseke T, Fawole OA. Micro-encapsulation of phytochemicals in passion fruit peel waste generated on an organic farm: Effect of carriers on the quality of encapsulated powders and potential for value-addition. Antioxidants 2022; 11(8): 1579.
[http://dx.doi.org/10.3390/antiox11081579] [PMID: 36009296]
[69]
Castaldo L, Izzo L, Gaspari A, et al. Chemical composition of green pea (Pisum sativum L.) pods extracts and their potential exploitation as ingredients in nutraceutical formulations. Antioxidants 2021; 11(1): 105.
[http://dx.doi.org/10.3390/antiox11010105] [PMID: 35052609]
[70]
Dotto JM, Chacha JS. The potential of pumpkin seeds as a functional food ingredient: A review. Sci Am 2020; 10: e00575.
[71]
Allaqaband S, Dar AH, Patel U, et al. Utilization of fruit seed-based bioactive compounds for formulating the nutraceuticals and functional food: A review. Front Nutr 2022; 9: 902554.
[http://dx.doi.org/10.3389/fnut.2022.902554] [PMID: 35677543]
[72]
Obidiegwu JE, Lyons JB, Chilaka CA. The Dioscorea Genus (Yam)—an appraisal of nutritional and therapeutic potentials. Foods 2020; 9(9): 1304.
[http://dx.doi.org/10.3390/foods9091304] [PMID: 32947880]
[73]
Gamba M, Asllanaj E, Raguindin PF, et al. Nutritional and phytochemical characterization of radish (Raphanus sativus): A systematic review. Trends Food Sci Technol 2021; 113: 205-18.
[http://dx.doi.org/10.1016/j.tifs.2021.04.045]
[74]
Sorrenti V, Burò I, Consoli V, Vanella L. Recent advances in health benefits of bioactive compounds from food wastes and by-products: Biochemical aspects. Int J Mol Sci 2023; 24(3): 2019.
[http://dx.doi.org/10.3390/ijms24032019] [PMID: 36768340]
[75]
Tlais AZA, Fiorino GM, Polo A, Filannino P, Di Cagno R. High-value compounds in fruit, vegetable and cereal byproducts: An overview of potential sustainable reuse and exploitation. Molecules 2020; 25(13): 2987.
[http://dx.doi.org/10.3390/molecules25132987] [PMID: 32629805]
[76]
Rao VA, Kim JJ, Patel DS, Rains K, Estoll CR. A comprehensive scientific survey of excipients used in currently marketed, therapeutic biological drug products. Pharm Res 2020; 37(10): 200.
[http://dx.doi.org/10.1007/s11095-020-02919-4] [PMID: 32968854]
[77]
Žagar J, Mihelič J. Big data collection in pharmaceutical manufacturing and its use for product quality predictions. Sci Data 2022; 9(1): 99.
[http://dx.doi.org/10.1038/s41597-022-01203-x] [PMID: 35322032]
[78]
Benucci I, Lombardelli C, Mazzocchi C, Esti M. Natural colorants from vegetable food waste: Recovery, regulatory aspects, and stability—A review. Compr Rev Food Sci Food Saf 2022; 21(3): 2715-37.
[http://dx.doi.org/10.1111/1541-4337.12951] [PMID: 35368140]
[79]
Tylewicz U, Tappi S, Nowacka M, Wiktor A. Safety, quality, and processing of fruits and vegetables. Foods 2019; 8(11): 569.
[http://dx.doi.org/10.3390/foods8110569] [PMID: 31766141]
[80]
Slavin JL, Lloyd B. Health benefits of fruits and vegetables. Adv Nutr 2012; 3(4): 506-16.
[http://dx.doi.org/10.3945/an.112.002154] [PMID: 22797986]
[81]
Sharma S, Singh A, Sharma S, et al. Functional foods as a formulation ingredients in beverages: Technological advancements and constraints. Bioengineered 2021; 12(2): 11055-75.
[http://dx.doi.org/10.1080/21655979.2021.2005992] [PMID: 34783642]
[82]
Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med 2014; 5(12): 1487-99.
[PMID: 25709784]
[83]
Puebla-Barragan S, Reid G. Probiotics in cosmetic and personal care products: Trends and challenges. Molecules 2021; 26(5): 1249.
[http://dx.doi.org/10.3390/molecules26051249] [PMID: 33652548]
[84]
Williams PEV. Engineering plants for animal feed for improved nutritional value. Proc Nutr Soc 2003; 62(2): 301-9.
[http://dx.doi.org/10.1079/PNS2003250] [PMID: 14506877]
[85]
Baghi F, Gharsallaoui A, Dumas E, Ghnimi S. Advancements in biodegradable active films for food packaging: Effects of nano/microcapsule incorporation. Foods 2022; 11(5): 760.
[http://dx.doi.org/10.3390/foods11050760] [PMID: 35267394]
[86]
Bušić A, Kundas S, Morzak G, et al. Recent trends in biodiesel and biogas production. Food Technol Biotechnol 2018; 56(2): 152-73.
[http://dx.doi.org/10.17113/ftb.56.02.18.5547] [PMID: 30228791]
[87]
Boeing H, Bechthold A, Bub A, et al. Critical review: Vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 2012; 51(6): 637-63.
[http://dx.doi.org/10.1007/s00394-012-0380-y] [PMID: 22684631]
[88]
Wang PY, Fang JC, Gao ZH, Zhang C, Xie SY. Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes: A meta‐analysis. J Diabetes Investig 2016; 7(1): 56-69.
[http://dx.doi.org/10.1111/jdi.12376] [PMID: 26816602]
[89]
Postema P, Wilde A. The measurement of the QT interval. Curr Cardiol Rev 2014; 10(3): 287-94.
[http://dx.doi.org/10.2174/1573403X10666140514103612] [PMID: 24827793]
[90]
Ko K, Dadmohammadi Y, Abbaspourrad A. Nutritional and bioactive components of pomegranate waste used in food and cosmetic applications: A review. Foods 2021; 10(3): 657.
[http://dx.doi.org/10.3390/foods10030657] [PMID: 33808709]
[91]
Baroi AM, Popitiu M, Fierascu I, Sărdărescu ID, Fierascu RC. Grapevine wastes: A rich source of antioxidants and other biologically active compounds. Antioxidants 2022; 11(2): 393.
[http://dx.doi.org/10.3390/antiox11020393] [PMID: 35204275]
[92]
Hughes RG, Blegen MA. Medication administration safety. In: Patient safety and quality: An evidence-based handbook for nurses. 2008.
[93]
Claudio L. Our food: Packaging & public health. Environ Health Perspect 2012; 120(6): A232-7.
[http://dx.doi.org/10.1289/ehp.120-a232] [PMID: 22659036]
[94]
Pérez-Marroquín XA, Estrada-Fernández AG, García-Ceja A, Aguirre-Álvarez G, León-López A. Agro-food waste as an ingredient in functional beverage processing: Sources, functionality, market and regulation. Foods 2023; 12(8): 1583.
[http://dx.doi.org/10.3390/foods12081583] [PMID: 37107379]
[95]
Müller P, Schmid M. Intelligent packaging in the food sector: A brief overview. Foods 2019; 8(1): 16.
[http://dx.doi.org/10.3390/foods8010016] [PMID: 30621006]
[96]
Ncube LK, Ude AU, Ogunmuyiwa EN, Zulkifli R, Beas IN. Environmental impact of food packaging materials: A review of contemporary development from conventional plastics to polylactic acid based materials. Materials 2020; 13(21): 4994.
[http://dx.doi.org/10.3390/ma13214994] [PMID: 33171895]
[97]
Lebelo K, Malebo N, Mochane MJ, Masinde M. Chemical contamination pathways and the food safety implications along the various stages of food production: A review. Int J Environ Res Public Health 2021; 18(11): 5795.
[http://dx.doi.org/10.3390/ijerph18115795] [PMID: 34071295]
[98]
Palleria C, Di Paolo A, Giofrè C, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci 2013; 18(7): 601-10.
[PMID: 24516494]
[99]
Campos DA, Gómez-García R, Vilas-Boas AA, Madureira AR, Pintado MM. Management of fruit industrial by-products—a case study on circular economy approach. Molecules 2020; 25(2): 320.
[http://dx.doi.org/10.3390/molecules25020320] [PMID: 31941124]
[100]
Laufenberg G, Kunz B, Nystroem M. Transformation of vegetable waste into value added products. Bioresour Technol 2003; 87(2): 167-98.
[http://dx.doi.org/10.1016/S0960-8524(02)00167-0] [PMID: 12765356]
[101]
Bhatia L, Jha H, Sarkar T, Sarangi PK. Food waste utilization for reducing carbon footprints towards sustainable and cleaner environment: A review. Int J Environ Res Public Health 2023; 20(3): 2318.
[http://dx.doi.org/10.3390/ijerph20032318] [PMID: 36767685]
[102]
Yang M, Chen L, Wang J, et al. Circular economy strategies for combating climate change and other environmental issues. Environ Chem Lett 2023; 21(1): 55-80.
[http://dx.doi.org/10.1007/s10311-022-01499-6]
[103]
Ncube LK, Ude AU, Ogunmuyiwa EN, Zulkifli R, Beas IN. An overview of plastic waste generation and management in food packaging industries. Recycling 2021; 6(1): 12.
[http://dx.doi.org/10.3390/recycling6010012]
[104]
Marcillo-Parra V, Tupuna-Yerovi DS, González Z, Ruales J. Encapsulation of bioactive compounds from fruit and vegetable by-products for food application – A review. Trends Food Sci Technol 2021; 116: 11-23.
[http://dx.doi.org/10.1016/j.tifs.2021.07.009]
[105]
Pradhan P, Kriewald S, Costa L, et al. Urban food systems: How regionalization can contribute to climate change mitigation. Environ Sci Technol 2020; 54(17): 10551-60.
[http://dx.doi.org/10.1021/acs.est.0c02739] [PMID: 32701271]
[106]
Baranwal J, Barse B, Fais A, Delogu GL, Kumar A. Biopolymer: A sustainable material for food and medical applications. Polymers 2022; 14(5): 983.
[http://dx.doi.org/10.3390/polym14050983] [PMID: 35267803]

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Request history8.2.27PHP Version217msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
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    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
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      940μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
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      130μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 221938058 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221938058) limit 1
      17.95msalphaeurekaselec_live_10_06_2022UserAccess.php#784
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      • 5: 221938058
      • 6: 221938058
      • 7: 221938058
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      • 11: 221938058
      • 12: 221938058
      • 13: 221938058
      • 14: 221938058
      • 15: 221938058
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=137663
      820μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 212 limit 1
      420μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 212
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=212) and sj.journal_id!=212 group by `j`.`nid`) as `aggregate_table`
      670μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=212) and sj.journal_id!=212 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      590μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=212) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.03msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=212) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      730μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '137663'
      180μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 137663
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '137663'
      3.83msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 137663
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '137663' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      700μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 137663
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      430μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 212 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      7.5msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 212 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      470μsalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 212 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      410μsalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 137663 limit 1
      160μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 137663
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 137663 and content_type = 'article' order by status desc limit 1
      220μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 225963 limit 1
      160μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 225963
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      190μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'LFF' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      210μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: LFF
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '137663' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      350μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12541' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      290μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3278' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      260μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3278) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3278) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3278)
      11.01msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12541) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12541) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12541)
      750μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 137663) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 137663) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221938058 and j.to_ip >=221938058 )) and ((j.from_date <= 1739834392 and j.to_date >= 1739834392 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 137663)
      760μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '58' and is_uploaded = 1 and issue_id = 12541 order by cast(first_page as SIGNED) desc limit 1
      430μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 58
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '74' and is_uploaded = 1 and issue_id = 12541 order by cast(first_page as SIGNED) asc limit 1
      410μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 74
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      150μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 137663 limit 1
      2.38msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 137663
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 212 and `b`.`banner_from_date` <= 1739834392 and `b`.`banner_to_date` >= 1739834392 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 212
      • 3: 1739834392
      • 4: 1739834392
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 212 and `b`.`banner_from_date` <= 1739834392 and `b`.`banner_to_date` >= 1739834392 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.42msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 212
      • 3: 1739834392
      • 4: 1739834392
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='944e7fbe7c6d2eef2a3d826adbe74156'
      220μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
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        PHPDEBUGBAR_STACK_DATA
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        path_info
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        status_code
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        status_text
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        format
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        content_type
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        request_query
        []
        
        request_request
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        request_headers
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        request_cookies
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:19:52GET/article/137663514361