Abstract
Due to its extensive applications in the field of pharmaceutical chemistry and its potent biological and pharmacological activities, including analgesic, antioxidant, antimicrobial, anticancer, ant-inflammatory, anti-tubercular, antihyperlipidemic, antihistamine, antiviral, anticonvulsant and antiparkinsonian, the heterocyclic molecule occupies a distinct place in the scientific community. The discovery that many synthetic quinazolinone derivatives exhibit a wide range of biological functions has sparked interest in this area of study.
The purpose of this review is to collate literature work reported by researchers on quinazolinone and its derivatives for their various pharmacological activities.
[http://dx.doi.org/10.1016/j.bfopcu.2013.08.003]
[http://dx.doi.org/10.9790/3013-021097104]
[http://dx.doi.org/10.1155/2014/212096] [PMID: 25548779]
[http://dx.doi.org/10.3390/molecules161210187] [PMID: 22157581]
[http://dx.doi.org/10.1016/j.bmcl.2015.01.010] [PMID: 25638040]
[http://dx.doi.org/10.1016/j.jscs.2012.02.002]
[PMID: 24250506]
[http://dx.doi.org/10.1186/1752-153X-7-95] [PMID: 23731671]
[http://dx.doi.org/10.1016/j.arabjc.2014.07.001]
[http://dx.doi.org/10.1016/j.arabjc.2014.10.025]
[http://dx.doi.org/10.1016/j.jsps.2013.03.004] [PMID: 24648828]
[http://dx.doi.org/10.1186/1476-511X-4-22] [PMID: 16202158]
[http://dx.doi.org/10.1016/j.jscs.2012.02.006]
[http://dx.doi.org/10.1046/j.1469-0691.2003.00570.x] [PMID: 12667250]
[http://dx.doi.org/10.4155/fmc.10.16] [PMID: 21426007]
[http://dx.doi.org/10.1016/j.arabjc.2010.09.014]
[http://dx.doi.org/10.1016/j.bmc.2006.08.030] [PMID: 16971132]
[http://dx.doi.org/10.1016/j.bmc.2005.09.064] [PMID: 16263296]
[http://dx.doi.org/10.1016/j.bmcl.2007.07.091] [PMID: 17804225]
[http://dx.doi.org/10.1016/j.bmcl.2008.12.038] [PMID: 19109016]
[http://dx.doi.org/10.1016/j.bmcl.2009.05.113] [PMID: 19541484]
[http://dx.doi.org/10.1002/ardp.200390011] [PMID: 12761762]
[http://dx.doi.org/10.1007/BF01630479] [PMID: 7664022]
[http://dx.doi.org/10.2174/0929867003374255] [PMID: 11032964]
[http://dx.doi.org/10.1016/S0968-0896(03)00501-7] [PMID: 14604693]
[http://dx.doi.org/10.1016/j.bmc.2006.09.065] [PMID: 17079148]
[http://dx.doi.org/10.1155/2009/507052]
[http://dx.doi.org/10.1016/j.ejmech.2008.10.031] [PMID: 19064304]
[http://dx.doi.org/10.1248/yakushi.131.1079] [PMID: 21720138]
[http://dx.doi.org/10.1155/2013/907525]
[http://dx.doi.org/10.1016/j.bmc.2016.06.026] [PMID: 27344214]
[http://dx.doi.org/10.1016/j.jtusci.2016.10.003]
[http://dx.doi.org/10.13005/ojc/330217]
[http://dx.doi.org/10.1007/s00044-007-9047-2]
[http://dx.doi.org/10.1016/j.arabjc.2010.07.005]
[http://dx.doi.org/10.1016/j.bmcl.2011.05.031] [PMID: 21658941]
[http://dx.doi.org/10.1016/j.ejmech.2011.03.041] [PMID: 21481990]
[http://dx.doi.org/10.1016/j.jscs.2011.07.005]
[http://dx.doi.org/10.1016/j.jscs.2011.02.003]
[http://dx.doi.org/10.33786/JCPR.2012.v03i01.003]
[http://dx.doi.org/10.1007/s00044-011-9621-5]
[PMID: 22224092]
[PMID: 23181085]
[PMID: 23181076]
[PMID: 23181093]
[http://dx.doi.org/10.1016/j.bmcl.2013.08.068] [PMID: 24044873]
[http://dx.doi.org/10.1016/j.jscs.2011.04.001]
[PMID: 23329529]
[http://dx.doi.org/10.1016/j.ejmech.2012.12.061] [PMID: 23454532]
[http://dx.doi.org/10.2478/acph-2013-0006] [PMID: 23482309]
[http://dx.doi.org/10.1080/10426507.2013.829839]
[http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21329]
[http://dx.doi.org/10.1016/0006-2952(95)02156-6] [PMID: 8534268]
[http://dx.doi.org/10.1016/S0014-5793(03)01362-0] [PMID: 14706823]
[http://dx.doi.org/10.1016/j.farmac.2003.10.006] [PMID: 15178307]
[http://dx.doi.org/10.1016/j.ejmech.2003.12.009] [PMID: 15072839]
[http://dx.doi.org/10.1016/j.ejmech.2008.09.015] [PMID: 18950904]
[http://dx.doi.org/10.1016/j.ejmech.2010.10.008] [PMID: 21051122]
[http://dx.doi.org/10.1016/j.bmc.2010.03.019] [PMID: 20350811]
[http://dx.doi.org/10.1016/j.ejmech.2011.03.015] [PMID: 21458891]
[http://dx.doi.org/10.5430/jst.v5n2p73]
[http://dx.doi.org/10.4103/1735-5362.212046] [PMID: 28855940]
[http://dx.doi.org/10.1016/j.jsps.2017.04.022] [PMID: 29158714]
[http://dx.doi.org/10.1186/s13065-017-0333-x]
[http://dx.doi.org/10.4103/1735-5362.236838] [PMID: 30271447]
[http://dx.doi.org/10.1021/acs.jmedchem.7b01474] [PMID: 29227648]
[http://dx.doi.org/10.4103/1735-5362.253360] [PMID: 31620189]
[http://dx.doi.org/10.4103/1735-5362.253358] [PMID: 31620187]
[http://dx.doi.org/10.1016/j.cdc.2020.100546]
[http://dx.doi.org/10.1002/ardp.19833160906] [PMID: 6416222]
[http://dx.doi.org/10.4103/0250-474X.119832] [PMID: 24302802]
[http://dx.doi.org/10.1039/c3ob41896k] [PMID: 24158720]
[http://dx.doi.org/10.1007/s00044-014-1020-2]
[http://dx.doi.org/10.1016/j.bmcl.2016.09.043] [PMID: 27671498]
[http://dx.doi.org/10.1016/j.bmc.2018.08.034] [PMID: 30190182]
[http://dx.doi.org/10.1021/acsinfecdis.7b00275] [PMID: 29522317]
[http://dx.doi.org/10.1039/C8NJ04936J]
[http://dx.doi.org/10.26452/ijrps.v10i4.1590]
[http://dx.doi.org/10.2174/1573407214666180710143557]
[http://dx.doi.org/10.1021/jm00163a027] [PMID: 2296016]
[http://dx.doi.org/10.1002/1521-4184(20008)333:8<261::AID-ARDP261>3.0.CO;2-O] [PMID: 11008376]
[http://dx.doi.org/10.3390/molecules13102557] [PMID: 18927518]
[http://dx.doi.org/10.1016/j.ejmech.2009.05.008] [PMID: 19674817]
[http://dx.doi.org/10.1007/s00044-012-0280-y]
[http://dx.doi.org/10.1007/s00044-013-0569-5]
[http://dx.doi.org/10.1016/j.jtumed.2013.11.009]
[http://dx.doi.org/10.5530/jyp.2015.4.4]
[http://dx.doi.org/10.1039/C6RA01284A]
[http://dx.doi.org/10.1002/ardp.201600332]
[http://dx.doi.org/10.1021/jm9506938] [PMID: 8691473]
[http://dx.doi.org/10.1016/j.arabjc.2011.05.009]
[http://dx.doi.org/10.1002/ardp.19913240507] [PMID: 1679625]
[http://dx.doi.org/10.1248/bpb.26.1278] [PMID: 12951471]
[http://dx.doi.org/10.1177/095632020701800506] [PMID: 18046963]
[http://dx.doi.org/10.1111/cbdd.12589]
[http://dx.doi.org/10.1007/s00044-017-2083-7]
[http://dx.doi.org/10.1248/cpb.43.2021] [PMID: 8575039]
[http://dx.doi.org/10.1007/s12039-010-0052-5]
[http://dx.doi.org/10.1016/j.jksus.2018.10.003]
[http://dx.doi.org/10.1021/acs.jmedchem.6b00372] [PMID: 27088777]
[http://dx.doi.org/10.1016/j.bmcl.2017.09.026] [PMID: 28943043]
[http://dx.doi.org/10.1021/acs.jafc.0c05475] [PMID: 33872004]
[http://dx.doi.org/10.1021/acs.jmedchem.1c00441] [PMID: 34437804]