Recent Developments in Multi-component Synthesis of Lawsone Derivatives

Komal      Chandrakar; Jeevan   Lal   Patel; Rajeswar   Rao   Vedula; R. K.      Virendra; Shayama   Prasad   Mahapatra; Santhosh      Penta; Rajender   S.   Varma
doi:10.2174/1570179419666220401121714
Abstract

Background: 2-Hydroxy-1,4-Naphthoquinone (HNQ; Lawsone) is one of the most useful and the simplest naturally occurring naphthoquinones and has stimulated a resurgence of interest in the past decades due to a wide range of pharmacological activities.
Introduction and Methods: This activity has led to the unusually large emphasis being placed on the design of more efficient multi-component reactions (MCRs) in the synthesis of bioactive lawsone derivatives.
Results and Conclusion: This review highlights the recent developments in multi-component synthesis of biologically relevant naphthoquinone linked and fused heterocyclic derivatives carried out from 2015 till now.
Keywords: Lawsone derived heterocycles, multi-component reactions, one-pot synthesis, nanocatalysis, ultrasound irradiation, microwave irradiation.
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DOI https://dx.doi.org/10.2174/1570179419666220401121714	Print ISSN 1570-1794
Publisher Name Bentham Science Publisher	Online ISSN 1875-6271
Current Organic Synthesis

Recent Developments in Multi-component Synthesis of Lawsone Derivatives

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