Antinociceptive Investigations of Niranthin in Complete Freund’s Adjuvant- induced Chronic Pain in Mice

Title:Antinociceptive Investigations of Niranthin in Complete Freund’s Adjuvant- induced Chronic Pain in Mice

Volume: 15 Issue: 2

Author(s): Atul R. Chopade*, Vijay R. Salunkhe, Pramod A. Patil, Madhav R. Burade, Prakash M. Somade, Suraj N. Mali and Anima Pandey

Affiliation:

• Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, District - Sangli, Maharashtra 415404, India

Keywords: Niranthin, antinociceptive activity, hypersensitivity, aesthesiometer, somatic inflammatory pain, Freund’s adjuvant.

Abstract:

Objective: The main objectives of the present work are to determine the clinical effect of niranthin on visceral or somatic inflammatory pain. The study was performed to determine the effects of niranthin on visceral or somatic inflammatory hypersensitivity of adult Swiss albino mice by using complete Freund’s adjuvant (CFA) induced pain model.

Methods: The effect of CFA injection was determined after 24 hours of injection by using an aesthesiometer such as Von Frey filaments to evaluate tactile acetone-evoked cooling and thermal sensitivity. We used a digital Plethysmometer to measure paw edema. Single dose of niranthin intraperitoneal injection (5 and 10 mg/kg) was injected into mice having CFA-induced mechanical hypersensitivity and after 30 minutes of administration, reduced mechanical hypersensitivity was observed. In addition, niranthin also reduced acetone-evoked hypersensitivity within 4 hours.

Results: Compared to DMSO, niranthin was most highly active to reduce CFA-induced paw edema. To reduce mechanical hypersensitivity, multiple doses of niranthin (bis in die (b.i.d.)) from 1st - 5th day and b.i.d. day 9th and 10th) were given and remarkable results were observed such as did not cause tolerance in multiple dosing and significantly reduced in CFA induced hypersensitivity.

Conclusion: This work reported niranthin having antinociceptive activity and indicated that niranthin is conventionally active in the management of persistent pain.

Cite this article as:

Chopade R. Atul*, Salunkhe R. Vijay, Patil A. Pramod, Burade R. Madhav, Somade M. Prakash, Mali N. Suraj and Pandey Anima, Antinociceptive Investigations of Niranthin in Complete Freund’s Adjuvant- induced Chronic Pain in Mice, Recent Advances in Inflammation & Allergy Drug Discovery 2021; 15 (2) . https://dx.doi.org/10.2174/2772270816666220105122956