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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Krebs Cycle Rewired: Driver of Atherosclerosis Progression?

Author(s): Yamin Liang, Yanmei Chen, Lu Li, Shulei Zhang, Jinyan Xiao* and Dangheng Wei*

Volume 29, Issue 13, 2022

Published on: 06 August, 2021

Page: [2322 - 2333] Pages: 12

DOI: 10.2174/0929867328666210806105246

Price: $65

Abstract

The tricarboxylic acid (TCA) cycle is the center of energy metabolism in eukaryotic cells and is dynamically adjusted according to the energy needs of cells. Macrophages are activated by inflammatory stimuli, and then two breakpoints in TCA cycle lead to the accumulation of intermediates. Atherosclerosis is a chronic inflammatory process. Here, the "non-metabolic" signaling functions of TCA cycle intermediates in the macrophage under inflammatory stimulation and the role of intermediates in the progression of atherosclerosis are discussed.

Keywords: TCA cycle, citrate, succinate, itaconate, GPR91, atherosclerosis, fumarate.

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