Review Article

纳米粒子在体内的命运和设计用于药物递送的隐形纳米粒子的策略

卷 22, 期 8, 2021

发表于: 18 January, 2021

页: [922 - 946] 页: 25

弟呕挨: 10.2174/1389450122666210118105122

价格: $65

摘要

纳米药物递送系统(Nano-DDS)在药物递送和疾病靶向治疗方面具有强大的优势。与传统药物配方相比,Nano-DDS 可以提高溶解度、生物相容性,并减少游离药物的脱靶副作用。然而,它们仍然存在一些缺点,限制了它们在临床应用中的全部潜力。血液中的蛋白质吸附、补体系统的激活以及随后单核吞噬细胞系统 (MPS) 的隔离导致纳米颗粒 (NP) 从循环中迅速清除。因此,NPs 的药物递送效率较低。因此,开发隐形纳米颗粒以减少生物纳米相互作用非常重要。在这篇综述中,我们首先总结了 NPs 与生物环境之间的相互作用,如血液蛋白和 MPS,以及相互影响的因素。接下来,我们将根据目前对生物-纳米相互作用的了解,总结减少 MPS 对 NPs 蛋白质吸附和吸收的新策略。通过结合有针对性的策略以获得更好的治疗效果,仿生隐身纳米递送系统的发展也将被强调进一步的方向。

关键词: 纳米粒子、蛋白质电晕、免疫清除、防污、隐身、仿生隐身。

图形摘要

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