Abstract
Bladder cancer is the second most common malignancy of urinary tract. Normal bladder urothelium is a transitional epithelium which consist of 3-7 layers and three different types of cells. The question is what kind of cells is responsible for bladder cancer development, probably stem cells? Stem cells can be sensitive to changes in their environment including toxic substances related to smoking. These changes within stem cells may potentially induce carcinogenesis by limiting their differentiating potential but expanding their proliferative potential. This process is directly connected with stem cell senescence in which DNA alterations play an important role. Cancer stem cells have become the target in treating various cancers. Tumor initiating cells within bladder cancer have been isolated. It has to be tested what connections are between cancer stem cells and tumor initiating cells. Characteristic markers and proteins may help to identify bladder cancer stem cells and thus early stages of bladder cancer. Moreover, bladder cancer stem cells undergo signaling pathways which play critical role both in normal and cancer stem cells.
Keywords: Cancer stem cell, tumor biology, urinary bladder, carcinogenesis, phenotypic, metastatic, Neoplastic cells, post-mitotic, glycoproteins, lymphocyte
Current Signal Transduction Therapy
Title:Bladder Cancer and Stem Cells
Volume: 7 Issue: 3
Author(s): Tomasz Drewa, Sandra Krzyzanowska, Andrzej Marszalek and Anna Bajek
Affiliation:
Keywords: Cancer stem cell, tumor biology, urinary bladder, carcinogenesis, phenotypic, metastatic, Neoplastic cells, post-mitotic, glycoproteins, lymphocyte
Abstract: Bladder cancer is the second most common malignancy of urinary tract. Normal bladder urothelium is a transitional epithelium which consist of 3-7 layers and three different types of cells. The question is what kind of cells is responsible for bladder cancer development, probably stem cells? Stem cells can be sensitive to changes in their environment including toxic substances related to smoking. These changes within stem cells may potentially induce carcinogenesis by limiting their differentiating potential but expanding their proliferative potential. This process is directly connected with stem cell senescence in which DNA alterations play an important role. Cancer stem cells have become the target in treating various cancers. Tumor initiating cells within bladder cancer have been isolated. It has to be tested what connections are between cancer stem cells and tumor initiating cells. Characteristic markers and proteins may help to identify bladder cancer stem cells and thus early stages of bladder cancer. Moreover, bladder cancer stem cells undergo signaling pathways which play critical role both in normal and cancer stem cells.
Export Options
About this article
Cite this article as:
Drewa Tomasz, Krzyzanowska Sandra, Marszalek Andrzej and Bajek Anna, Bladder Cancer and Stem Cells, Current Signal Transduction Therapy 2012; 7 (3) . https://dx.doi.org/10.2174/157436212802481556
DOI https://dx.doi.org/10.2174/157436212802481556 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Systematic Review of the Uterine Relaxant Effect of Herbal Sources
Current Pharmaceutical Biotechnology Dexamethasone Reduces Cell Adhesion and Migration of T47D Breast Cancer Cell Line
Anti-Cancer Agents in Medicinal Chemistry Phosphodiesterase Type 5 Inhibitors: Unmet Needs
Current Pharmaceutical Design Circular RNAs and Glioma: Small Molecule with Big Actions
Current Molecular Medicine Spinal Microvascular Expression of PV-1 is Associated with Inflammation, Perivascular Astrocyte Loss, and Diminished EC Glucose Transport Potential in Acute SCI
Current Neurovascular Research Aloperine Induces Apoptosis by a Reactive Oxygen Species Activation Mechanism in Human Ovarian Cancer Cells
Protein & Peptide Letters Cytokinin Nucleosides - Natural Compounds with a Unique Spectrum of Biological Activities
Current Topics in Medicinal Chemistry Hollow Inorganic Nanoparticles as Efficient Carriers for siRNA Delivery: A Comprehensive Review
Current Pharmaceutical Design Drug Targeting Approaches and Use of Drug Delivery Systems in Management of Cancer
Current Pharmaceutical Design Hapten Recognition by T Cells: A Functional and Molecular View
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Immune Receptors, Cadherins and their Interactions
Current Immunology Reviews (Discontinued) The Epidemiological, Mechanistic and Potential Clinical Role of Androgen Receptor (AR) in Urothelial Carcinoma
Current Drug Targets The Role of Iron Chelation in Cancer Therapy
Current Medicinal Chemistry Hydrogen Sulphide and Pain
Inflammation & Allergy - Drug Targets (Discontinued) Preface: [Hot topic: Metal Compounds in Medicinal Chemistry (Executive Editor: Dinorah Gambino)]
Mini-Reviews in Medicinal Chemistry Meet the Editorial Board Member
Recent Advances in Drug Delivery and Formulation Identification and Characterization of New Proteins in Podocyte Dysfunction of Membranous Nephropathy by Proteomic Analysis of Renal Biopsy
Current Pharmacogenomics and Personalized Medicine Rapid Nucleic Acid Reaction Circuits for Point-of-care Diagnosis of Diseases
Current Topics in Medicinal Chemistry Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora
Medicinal Chemistry Small-molecule Inhibitors of Epigenetic Mutations as Compelling Drugtargets for Myelodysplastic Syndromes
Current Cancer Drug Targets