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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

Evolution of Writing Impairment in Spanish Patients with Alzheimer's Disease

Author(s): María González-Nosti*, Fernando Cuetos and Carmen Martínez

Volume 17, Issue 9, 2020

Page: [845 - 857] Pages: 13

DOI: 10.2174/1567205017666201204162837

Price: $65

Abstract

Background: Although some studies suggest that writing difficulties may be one of the early symptoms of Alzheimer's disease (AD), they have been scarcely studied compared to oral language. Particularly noteworthy is the paucity of longitudinal studies that enable the observation of writing impairment as cognitive decline progresses.

Objective: The aim of this study was to examine the characteristics of writing in patients with AD and to monitor the deterioration of their performance over a follow-up period.

Methods: Sixty-four participants (half with AD and half healthy elderly) were compared in a word and pseudo-word dictation task. Patients were evaluated every 6 months over a 2.5 year follow-up period.

Results: The evolution of patient performance and error profile shows a typical pattern of deterioration, with early damage to the lexical pathway, which later extends to the phonological pathway and eventually affects peripheral processes.

Conclusion: These results confirm the presence of writing difficulties from the early stages of AD, supporting the value of this task for early diagnosis. Furthermore, it allows us to explain the contradictory data obtained in previous investigations.

Keywords: Alzheimer's disease, writing disorders, cognitive decline, dictation, spelling difficulties, longitudinal study.

[1]
Klimova b, Kuca K. Speech and language impairments in dementia. J Appl Biomed 2016; 14(2): 97-103.
[http://dx.doi.org/10.1016/j.jab.2016.02.002]
[2]
Fukui T, Lee E. Progressive agraphia can be a harbinger of degenerative dementia. Brain Lang 2008; 104(3): 201-10.
[http://dx.doi.org/10.1016/j.bandl.2007.10.005] [PMID: 18068758]
[3]
Croisile B. Writing, aging and Alzheimer’s disease. Psychol Neuropsychiatr Vieil 2005; 3(3): 183-97.
[PMID: 16126471]
[4]
Ellis AW. Spelling and writing (and reading and speaking) Normality and pathology in cognitive functions. London: Academic Press 1982; pp. 113-46.
[5]
Groves-Wright K, Neils-Strunjas J, Burnett R, O’Neill MJ. A comparison of verbal and written language in Alzheimer’s disease. J Commun Disord 2004; 37(2): 109-30.
[http://dx.doi.org/10.1016/j.jcomdis.2003.08.004] [PMID: 15013729]
[6]
Hughes JC, Graham N, Patterson K, Hodges JR. Dysgraphia in mild dementia of Alzheimer’s type. Neuropsychologia 1997; 35(4): 533-45.
[http://dx.doi.org/10.1016/S0028-3932(96)00102-9] [PMID: 9106281]
[7]
Rapcsak SZ, Arthur SA, Bliklen DA, Rubens AB. Lexical agraphia in Alzheimer’s disease. Arch Neurol 1989; 46(1): 65-8.
[http://dx.doi.org/10.1001/archneur.1989.00520370067021] [PMID: 2910263]
[8]
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12(3): 189-98.
[http://dx.doi.org/10.1016/0022-3956(75)90026-6] [PMID: 1202204]
[9]
Cuetos F, Martinez T, Martinez C, Izura C, Ellis AW. Lexical processing in Spanish patients with probable Alzheimer’s disease. Brain Res Cogn Brain Res 2003; 17(3): 549-61.
[http://dx.doi.org/10.1016/S0926-6410(03)00169-1] [PMID: 14561444]
[10]
Rodríguez-Ferreiro J, Martínez C, Pérez-Carbajal A-J, Cuetos F. Neural correlates of spelling difficulties in Alzheimer’s disease. Neuropsychologia 2014; 65(0): 12-7.
[http://dx.doi.org/10.1016/j.neuropsychologia.2014.10.006] [PMID: 25447060]
[11]
Luzzatti C, Laiacona M, Agazzi D. Multiple patterns of writing disorders in dementia of the Alzheimer type and their evolution. Neuropsychologia 2003; 41(7): 759-72.
[http://dx.doi.org/10.1016/S0028-3932(02)00328-7] [PMID: 12631527]
[12]
Eustache F, Lambert J. Neuro-cognitive models of spelling and Alzheimer disease: mutual clarification. Rev Neurol (Paris) 1996; 152(11): 658-68.
[PMID: 9033940]
[13]
Lambert J, Giffard B, Nore F, de la Sayette V, Pasquier F, Eustache F. Central and peripheral agraphia in Alzheimer’s disease: From the case of Auguste D to a cognitive neuropsychology approach. Cortex 2007; 43(7): 935-51.
[http://dx.doi.org/10.1016/S0010-9452(08)70692-0] [PMID: 17941351]
[14]
Silveri MC, Corda F, Di Nardo M. Central and peripheral aspects of writing disorders in Alzheimer’s disease. J Clin Exp Neuropsychol 2007; 29(2): 179-86.
[http://dx.doi.org/10.1080/13803390600611351] [PMID: 17365253]
[15]
Neils J, Roeltgen DP, Greer A. Spelling and attention in early Alzheimer’s disease: Evidence for impairment of the graphemic buffer. Brain Lang 1995; 49(3): 241-62.
[http://dx.doi.org/10.1006/brln.1995.1032] [PMID: 7640965]
[16]
Cortese MJ, Balota DA, Sergent-Marshall SD, Buckner RL. Spelling via semantics and phonology: Exploring the effects of age, Alzheimer’s disease, and primary semantic impairment. Neuropsychologia 2003; 41(8): 952-67.
[http://dx.doi.org/10.1016/S0028-3932(02)00320-2] [PMID: 12667531]
[17]
Aarsland D, Høien T, Larsen JP, Oftedal M. Lexical and nonlexical spelling deficits in dementia of the Alzheimer type. Brain Lang 1996; 52(3): 551-63.
[http://dx.doi.org/10.1006/brln.1996.0029] [PMID: 8653395]
[18]
Pestell S, Shanks MF, Warrington J, Venneri A. Quality of spelling breakdown in Alzheimer’s disease is independent of disease progression. J Clin Exp Neuropsychol 2000; 22(5): 599-612.
[http://dx.doi.org/10.1076/1380-3395(200010)22:5;1-9;FT599] [PMID: 11094395]
[19]
Croisile B, Ska B, Brabant MJ, et al. Comparative study of oral and written picture description in patients with Alzheimer’s disease. Brain Lang 1996; 53(1): 1-19.
[http://dx.doi.org/10.1006/brln.1996.0033] [PMID: 8722896]
[20]
Platel H, Lambert J, Eustache F, et al. Characteristics and evolution of writing impairment in Alzheimer’s disease. Neuropsychologia 1993; 31(11): 1147-58.
[http://dx.doi.org/10.1016/0028-3932(93)90064-7] [PMID: 8107977]
[21]
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984; 34(7): 939-44.
[http://dx.doi.org/10.1212/WNL.34.7.939] [PMID: 6610841]
[22]
Galdós L, Manubens JM. Historia clínica, exploración física y neurológica y pruebas complementarias Guías en Demencias Conceptos, criterios y recomendaciones para el estudio del paciente con demencia Grupo de Estudio de Neurología de la Conducta y Demencias de la Sociedad Española de Neurología. Barcelona: Masson 2000.
[23]
Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982; 139(9): 1136-9.
[http://dx.doi.org/10.1176/ajp.139.9.1136] [PMID: 7114305]
[24]
Sebastián N, Martí MA, Carreiras MF, Cuetos F. LEXESP, Léxico informatizado del español. Barcelona: Ediciones de la Universitat de Barcelona 2000.
[25]
Pérez MA, Alameda JR, Cuetos F. Frecuencia, longitud y vecindad ortográfica de las palabras de 3 a 16 letras del Diccionario de la Lengua Española” (RAE, 1992). Revista Electrónica de Metodología Aplicada 2003; 8: 1-10.
[26]
Croisile B, Brabant MJ, Carmoi T, Lepage Y, Aimard G, Trillet M. Comparison between oral and written spelling in Alzheimer’s disease. Brain Lang 1996; 54(3): 361-87.
[http://dx.doi.org/10.1006/brln.1996.0081] [PMID: 8866054]
[27]
Beeson MP, Rapcsak SZ, Plante E, et al. The neural substrates of writing: A functional magnetic resonance imaging study. Aphasiology 2003; 17: 647-65.
[http://dx.doi.org/10.1080/02687030344000067]
[28]
Patterson KE, Kay J. Letter-by-letter reading: Psychological descriptions of a neurological syndrome. Q J Exp Psychol 1982; 34(A): 411-1.
[29]
Rapcsak SZ, Rubens AB, Laguna JF. From letters to words: Procedures for word recognition in letter-by-letter reading. Brain Lang 1990; 38(4): 504-14.
[http://dx.doi.org/10.1016/0093-934X(90)90134-3] [PMID: 2375979]

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