Abstract
Stroke caused by carotid atherosclerosis is a leading cause of mortality and the leading cause of disability in the developed world. For carotid plaques within the neurovascular territory of a recent stroke or transient ischaemic attack, surgical removal of the plaque (endarterectomy) has been clearly shown to reduce future cerebrovascular events. Management of asymptomatic plaques, however, is less clear because only a minority of these plaques will ultimately become symptomatic. Inflammation is a key feature which predicts whether a plaque is likely to rupture and hence lead to stroke. By identifying inflammation in vivo, positron emission tomography (PET) may be able to identify high risk plaques. This will allow clinicians to target intensive medical or surgical treatment to high risk patients.
Keywords: Atherosclerosis, carotid, imaging, inflammation, plaque, positron emission tomography.
Current Molecular Medicine
Title:Clinical Assessment of Carotid Atherosclerosis Inflammation by Positron Emission Tomography
Volume: 13 Issue: 10
Author(s): J. Shalhoub, Y. Oskrochi, A. H. Davies and D. R.J. Owen
Affiliation:
Keywords: Atherosclerosis, carotid, imaging, inflammation, plaque, positron emission tomography.
Abstract: Stroke caused by carotid atherosclerosis is a leading cause of mortality and the leading cause of disability in the developed world. For carotid plaques within the neurovascular territory of a recent stroke or transient ischaemic attack, surgical removal of the plaque (endarterectomy) has been clearly shown to reduce future cerebrovascular events. Management of asymptomatic plaques, however, is less clear because only a minority of these plaques will ultimately become symptomatic. Inflammation is a key feature which predicts whether a plaque is likely to rupture and hence lead to stroke. By identifying inflammation in vivo, positron emission tomography (PET) may be able to identify high risk plaques. This will allow clinicians to target intensive medical or surgical treatment to high risk patients.
Export Options
About this article
Cite this article as:
Shalhoub J., Oskrochi Y., Davies H. A. and Owen R.J. D., Clinical Assessment of Carotid Atherosclerosis Inflammation by Positron Emission Tomography, Current Molecular Medicine 2013; 13 (10) . https://dx.doi.org/10.2174/1566524013666131111130334
DOI https://dx.doi.org/10.2174/1566524013666131111130334 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Novel Anti-Platelets in Stable Coronary Artery Disease
Current Pharmaceutical Design Dietary Approaches and Alternative Therapies for Polycystic Ovary Syndrome
Current Nutrition & Food Science Editorial: Understanding Basic Muscle Electrophysiology While Keeping an Eye on Diseases of the Heart, Lung and Blood
Recent Patents on Cardiovascular Drug Discovery Alterations in the Vascular Reactivity of Aorta in the Early and Late Phase of Adjuvant-Induced Arthritis in Rat
Vascular Disease Prevention (Discontinued) Impact of Clinical Audit on Adherence to the Guidelines Directed Medical Therapy in Patients Admitted with Heart Failure
Current Drug Safety Modeling Loss of Microvascular Wall Homeostasis during Glycocalyx Deterioration and Hypertension that Impacts Plasma Filtration and Solute Exchange
Current Neurovascular Research Update on Glycoprotein IIb/IIIa: Role in Primary Coronary Intervention
Cardiovascular & Hematological Agents in Medicinal Chemistry Virulence Potential of Staphylococcus aureus Strains Isolated from Diabetic Foot Ulcers Among Patients from Southern Poland
Current Vascular Pharmacology Editorial [Hot topic: Modifying Cardiovascular Risk Factors: Epidemiology and Characteristics of Smoking-Related Cardiovascular Diseases (Executive Editor: Aurelio Leone)]
Current Pharmaceutical Design Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) Editorial [Hot Topic:Angiogenesis Agents(Executive Editor: Cezary Marcinkiewicz)]
Current Pharmaceutical Design Mechanisms of Protective Effects of SGLT2 Inhibitors in Cardiovascular Disease and Renal Dysfunction
Current Topics in Medicinal Chemistry Targeted Intraoperative Radiotherapy Tumour Bed Boost During Breast Conserving Surgery after Neoadjuvant Chemotherapy in HER2 Positive and Triple Negative Breast Cancer
Reviews on Recent Clinical Trials Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling
Cardiovascular & Hematological Disorders-Drug Targets <i>Ajuga</i> L.: A Systematic Review on Chemical Composition, Phytopharmacological and Biological Potential
Current Bioactive Compounds Cardiac Applications for Human Pluripotent Stem Cells
Current Pharmaceutical Design Analysis of Carotid Ultrasound Images for the Assessment of Stroke Risk Using Level Set Method
Current Medical Imaging The Effects of Drugs Used in Anaesthesia on Platelet Membrane Receptors and on Platelet Function
Medicinal Chemistry Reviews - Online (Discontinued) Contemporary Review of Drugs Used to Treat Obesity
Cardiovascular & Hematological Agents in Medicinal Chemistry Editorial: Multi-Target in Computer-Aided Drug Design Studies
Current Drug Targets