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Meta-Analysis

益生元产品对降低超重和肥胖个体肥胖参数的影响:一项系统综述和Meta分析

卷 28, 期 2, 2021

发表于: 30 December, 2019

页: [419 - 431] 页: 13

弟呕挨: 10.2174/0929867327666191230110128

价格: $65

摘要

背景：益生元是宿主微生物选择性利用的底物，对健康有益。一些临床和动物研究表明益生元具有降低超重/肥胖个体体重的潜力。然而，这些研究都是基于相对较小的样本量，而益生元产品的精确效果尚未得到评估。因此，本研究通过随机对照试验(RCTs)的荟萃分析，全面评估益生元产品对超重和肥胖个体的影响。 方法：检索PubMed、EMBASE和Cochrane图书馆，以确定RCT调查益生元产品对超重和肥胖个体的影响。我们计算了合并加权平均差(WMD)来评估益生元产品对身体质量指数(BMI)、体重、脂肪质量和炎症生物标志物的影响。 结果：共有535名超重和肥胖个体参加了12项随机对照试验。与安慰剂相比，益生元产品降低了C反应蛋白(WMD， -1.06 mg/L;95%CI， -1.72 ~ - 0.40;p=0.002)、肿瘤坏死因子-α(WMD， -0.64 pg/mL;95%CI， -1.11 ~ -0.18;p=0.006)和其他炎症标志物如白细胞介素-1β、脂多糖(p<0.05);BMI (WMD， -0.20 kg/m2;95%CI， -0.58 ~ 0.19;p=0.32)，体重(WMD， -0.51 kg;95%CI， -1.18 - 0.16;p=0.14)和脂肪质量(WMD, 0.11 kg;95%CI， -0.04 ~ 0.25;观察p = 0.15)。 结论：在目前的分析,全面的证据表明生命起源以前的产品没有减少肥胖症参数(体重指数、体重和体脂量),但他们可以减少系统性炎症生物标记物的水平,这意味着坚持生命起源以前的产品可能是一个有前途的互补方法管理炎症在超重和肥胖的人。

关键词: 益生元，超重，肥胖，炎症，肠道微生物群，meta分析，BMI。

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