Abstract
Solid-phase chemistry, first introduced for peptide synthesis in the 1960s, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
Keywords: Pictet-Spengler reaction, dehydrative cyclization, antitumor, prostaglandin, Combinatorial libraries, galanthamine-like compounds, carpanone
Mini-Reviews in Medicinal Chemistry
Title: Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products
Volume: 6 Issue: 1
Author(s): Alvarez Cironi, Mercedes Alvarez and Fernando Albericio
Affiliation:
Keywords: Pictet-Spengler reaction, dehydrative cyclization, antitumor, prostaglandin, Combinatorial libraries, galanthamine-like compounds, carpanone
Abstract: Solid-phase chemistry, first introduced for peptide synthesis in the 1960s, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
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Cite this article as:
Cironi Alvarez, Alvarez Mercedes and Albericio Fernando, Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197857
DOI https://dx.doi.org/10.2174/138955706775197857 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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