Abstract
Polymersomes are self-assembled spherical vesicles based on amphiphilic block copolymers. This review presents a summary of the achievements in the field of polymersome researches to date. Polymersomes have been applied as versatile drug carriers. Some polymersomes, which have well-known stimuli-responsibility, can release drugs in a controlled manner at the target site when they are given a specific stimulation such as pH, temperature, light, magnetic field, hydrogen bond actions, electrostatic force or ultrasound. The preparation methods of polymersomes are similar to that of liposomes, including the thin film rehydration technique, solvent method, direct dissolution, double emulsion in microfluidic device, and electroformation. In addition, biologically active ligands, such as antibodies, can be readily conjugated onto the exterior brush surface of polymersomes to target the vesicles or to provide a therapeutic response. Polymersomes offer superior advantages for future clinical therapeutic and diagnostic imaging applications.
Keywords: Polymersomes, amphiphilic block copolymers, preparation, stimuli-responsive, therapeutic and diagnostic applications, drug carriers, liposomes, thin film rehydration technique, electroformation, antibodies
Current Pharmaceutical Design
Title:Recent Advances in Formation, Properties, and Applications of Polymersomes
Volume: 18 Issue: 23
Author(s): JinFeng Liao, Cheng Wang, YuJun Wang, Feng Luo and ZhiYong Qian
Affiliation:
Keywords: Polymersomes, amphiphilic block copolymers, preparation, stimuli-responsive, therapeutic and diagnostic applications, drug carriers, liposomes, thin film rehydration technique, electroformation, antibodies
Abstract: Polymersomes are self-assembled spherical vesicles based on amphiphilic block copolymers. This review presents a summary of the achievements in the field of polymersome researches to date. Polymersomes have been applied as versatile drug carriers. Some polymersomes, which have well-known stimuli-responsibility, can release drugs in a controlled manner at the target site when they are given a specific stimulation such as pH, temperature, light, magnetic field, hydrogen bond actions, electrostatic force or ultrasound. The preparation methods of polymersomes are similar to that of liposomes, including the thin film rehydration technique, solvent method, direct dissolution, double emulsion in microfluidic device, and electroformation. In addition, biologically active ligands, such as antibodies, can be readily conjugated onto the exterior brush surface of polymersomes to target the vesicles or to provide a therapeutic response. Polymersomes offer superior advantages for future clinical therapeutic and diagnostic imaging applications.
Export Options
About this article
Cite this article as:
Liao JinFeng, Wang Cheng, Wang YuJun, Luo Feng and Qian ZhiYong, Recent Advances in Formation, Properties, and Applications of Polymersomes, Current Pharmaceutical Design 2012; 18 (23) . https://dx.doi.org/10.2174/138161212801227050
DOI https://dx.doi.org/10.2174/138161212801227050 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Optical and Multimodal Peptide-Based Probes for In Vivo Molecular Imaging
Anti-Cancer Agents in Medicinal Chemistry Editorial (Hot Topic: Targeted Therapy of Malignant Brain Tumors)
Current Signal Transduction Therapy The Safety of the Temozolomide in Patients with Malignant Glioma
Current Drug Safety Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors
Current Medicinal Chemistry Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer
Current Drug Targets Poxvirus Cancer Therapy
Recent Patents on Anti-Infective Drug Discovery Combinations of Plant Polyphenols & Anti-Cancer Molecules: A Novel Treatment Strategy for Cancer Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Receptor Tyrosine Kinases as Therapeutic Targets in Malignant Glioma
Reviews on Recent Clinical Trials Monofunctional Platinum (PtII) Compounds – Shifting the Paradigm in Designing New Pt-based Anticancer Agents
Current Medicinal Chemistry Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis
Current Protein & Peptide Science Strategies to Overcome or Circumvent P-Glycoprotein Mediated Multidrug Resistance
Current Medicinal Chemistry Lipid Based Nanoparticles as Inherent Reversing Agents of Multidrug Resistance in Cancer
Current Pharmaceutical Design Activation of Sphingosine Kinase-1 in Cancer: Implications for Therapeutic Targeting
Current Molecular Pharmacology Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research
Current Drug Targets Angiogenesis New Targets for the Development of Anticancer Chemotherapies
Current Pharmaceutical Design The Synthesis, Structural Modification and Mode of Anticancer Action of Evodiamine: A Review
Recent Patents on Anti-Cancer Drug Discovery <sup>177</sup>Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay
Current Radiopharmaceuticals Targeting Epigenetics in Nervous System Disease
CNS & Neurological Disorders - Drug Targets Vascular Endothelial Growth Factor and Its Receptor as Drug Targets in Hematological Malignancies
Current Drug Targets Anticancer Advances of Matrine and Its Derivatives
Current Pharmaceutical Design