Perspectives on the Development of Novel Potentially Active Quinolones Against Tuberculosis and Cancer

V.      Facchinetti; C.      R.B. Gomes; M.      V.N. de Souza; T.      R.A. Vasconcelos

doi:10.2174/138955712800959099

Abstract

Quinolones and its derivatives comprise an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, antiviral, anti-ischemic, antiparasitic and anxiolytic. Persistent efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side-effects. The present review aims to highlight some recent discoveries on the development of novel quinolone-based compounds with potential antitubercular and anticancer activity.

Keywords: Biological activity, cancer, drugs, quinolones, tuberculosis, iodoanilines, BCG, Ciprofloxacin, in vitro, 6-nitroquinolones