Differences in Vanadocene Dichloride and Cisplatin Effect on MOLT-4 Leukemia and Human Peripheral Blood Mononuclear Cells

Title:Differences in Vanadocene Dichloride and Cisplatin Effect on MOLT-4 Leukemia and Human Peripheral Blood Mononuclear Cells

Volume: 8 Issue: 4

Author(s): Radim Havelek, Pavel Siman, Jana Cmielova, Alena Stoklasova, Jirina Vavrova, Jaromir Vinklarek, Jiri Knizek and Martina Rezacova

Affiliation:

Keywords: Cisplatin, Cytotoxicity, Leukemia, MOLT-4 Cell Line, Peripheral Blood Mononuclear Cells, Vanadocene Dichloride, metallocene antitumor agents, lymphoblastic leukemia, mononuclear cells, PBMCs

Abstract: Modern chemotherapy is interested in developing new agents with high efficiency of treatment in low-dose medication strategies, lower side toxicity and stronger specificity to the tumor cells. Vanadocene dichloride (VDC) belongs to the group of the most promising metallocene antitumor agents; however, its mechanism of action and cytotoxicity profile are not fully understood. In this paper we assess cytotoxic effects of VDC in comparison to cisplatin using opposite prototype of cells; human peripheral blood mononuclear (PBMCs) cells and human acute lymphoblastic leukemia cell line (MOLT-4). Our findings showed cytotoxic effect of VDC on leukemia cells, but unfortunately on human peripheral blood mononuclear cells as well. VDC induces apoptosis in leukemia cells; the induction is, however, lower than that of cisplatin, and in contrary to cisplatin, VDC does not induce p53 up-regulation. Cytotoxic effect of VDC on leukemia cells is less pronounced than that of cisplatin and more pronounced in PBMCs than in MOLT-4 cells.

Cite this article as:

Havelek Radim, Siman Pavel, Cmielova Jana, Stoklasova Alena, Vavrova Jirina, Vinklarek Jaromir, Knizek Jiri and Rezacova Martina, Differences in Vanadocene Dichloride and Cisplatin Effect on MOLT-4 Leukemia and Human Peripheral Blood Mononuclear Cells, Medicinal Chemistry 2012; 8 (4) . https://dx.doi.org/10.2174/157340612801216364