Abstract
Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, “oxidative stress” implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidativemodified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
Keywords: Reactive Oxygen Species (ROS), Oxidative Stress, Lipid Oxidation, DNA Oxidation, Protein Oxidation, Oral Carcinogenesis, OSCC, Leukoplakia, Lichen Planus, Submucous Fibrosis, tobacco, infection, intraoral cancer, chemotherapy, radiotherapy
Current Molecular Medicine
Title:Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone?
Volume: 12 Issue: 6
Author(s): R. Hanafi, I. Anestopoulos, G. P. Voulgaridou, R. Franco, A. G. Georgakilas, D. Ziech, V. Malamou-Mitsi, A. Pappa and M. I. Panayiotidis
Affiliation:
Keywords: Reactive Oxygen Species (ROS), Oxidative Stress, Lipid Oxidation, DNA Oxidation, Protein Oxidation, Oral Carcinogenesis, OSCC, Leukoplakia, Lichen Planus, Submucous Fibrosis, tobacco, infection, intraoral cancer, chemotherapy, radiotherapy
Abstract: Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, “oxidative stress” implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidativemodified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
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Hanafi R., Anestopoulos I., P. Voulgaridou G., Franco R., G. Georgakilas A., Ziech D., Malamou-Mitsi V., Pappa A. and I. Panayiotidis M., Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone?, Current Molecular Medicine 2012; 12 (6) . https://dx.doi.org/10.2174/156652412800792598
DOI https://dx.doi.org/10.2174/156652412800792598 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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