Antioxidant Nanoplatforms for Dermal Delivery: Melatonin

Title:Antioxidant Nanoplatforms for Dermal Delivery: Melatonin

Volume: 18 Issue: 5

Author(s): Aroha Sanchez Milan, Ana Cristina Calpena Campmany and Beatriz Clares Naveros*

Affiliation:

• Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Granada University, P.O. Box: 18071 (Campus of Cartuja St. s/n), Granada,Spain

Keywords: Antioxidants, melatonin, dermal delivery, nanosystems, pharmacokinetics, skin metabolism.

Abstract: Background: Melatonin is emerging as a promising therapeutic agent, mainly due to its role as antioxidant. Substantial evidences show that melatonin is potentially effective in a variety of diseases as cancer, inflammation and neurodegenerative diseases. The excellent antioxidant capacity with pharmacokinetics characteristics and the emerging search for new pharmaceutical nanotechnology based systems, make it particularly attractive to elaborate nanoplatforms based on melatonin for biomedical or cosmetic dermal applications. Different nanosystems for dermal delivery have been investigated.

Objective: This review focuses on nanocarrier production strategies, dermal melatonin application and delivery advances in vivo and in vitro. Equally, future perspectives of this assisted melatonin delivery have also been discussed.

Method: In the current review, we have revised relevant articles of the available literature using the major scientific databases.

Results: One hundred and thirteen papers were included in the review, the majority of which represent latest researches in nanosized platforms for the dermal delivery of melatonin including liposomes, ethosomes, niosomes, polymeric nanoparticles, solid lipid nanoparticles and cyclodextrins. Furthermore, relevant papers reporting in vitro and in vivo application studies of these nano-based melatonin platforms were also discussed.

Conclusion: The use of nanoplatforms for the dermal melatonin delivery as antioxidant agent could improve the efficacy of conventional melatonin administration due to the preservation of the drug from premature oxidation and the enhancement of drug permeation through the skin providing greater exposure times.

Cite this article as:

Milan Sanchez Aroha, Campmany Cristina Calpena Ana and Naveros Clares Beatriz*, Antioxidant Nanoplatforms for Dermal Delivery: Melatonin, Current Drug Metabolism 2017; 18 (5) . https://dx.doi.org/10.2174/1389200218666170222145908

DOI https://dx.doi.org/10.2174/1389200218666170222145908	Print ISSN 1389-2002
Publisher Name Bentham Science Publisher	Online ISSN 1875-5453