A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

Christiane      Meyre-Silva; Valdir      Cechinel-Filho

doi:10.2174/138161210793563392

Abstract

The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil. Some species are traditionally used to treat various diseases, including asthma, pulmonary infections, inflammation and hypotension, as cholagogues and sedative agents, and for pain relief. A literature review on the chemical and biological aspects of these plants indicates antimicrobial activity against gram positive bacteria, analgesic properties, and anti-hypertensive, antidiabetic, antioxidant properties, among others, particularly related to the presence of diterpenes, sterols, phenylpropanoids and flavonoids. This review shows the main chemical and pharmacological aspects of the genus Marrubium, with emphasis on M. vulgare, which grows in Brazil and has been studied by us and other authors.

Keywords: Marrubium, ethnopharmacology, chemical composition, M. vulgare, labdane terpenes, essential oils, analgesic and anti-inflammatory effects, antimicrobial, Lamiaceae, asthma, pulmonary infections, inflammation, hypotension, cholagogues, gram positive bacteria, analgesic properties, anti-hypertensive, antidiabetic, antioxidant properties, diterpenes, sterols, phenylpropanoids, flavonoids, analgesic andchemical, anti-inflammatory effects, antimicrobial, Marrubium vulgare, polyphenols, Marrubium alysson L, sitosterol glucoside (1), apigenin-7-O-arabonoside, apigenin-7-O-glucoside, verbascoside, leucosceptoside A, forsythoside B, leucosceptoside B, M. alysson, Candida glabrata, C. albicans, C. parapsilosis, C. kreusei, oleanolic, Lamiaceae family, Marrubium alternidens Rech, tannins, alkaloids, Marrubium astracanicum Jacq, beta-caryophyllene, valeranone, Marrubium bourgaei Boiss. ssp Caricum P.H., Eugenol, bisabolene, saponins, prefuranic labdane diterpene