Patent Foramen Ovale and Thromboembolic Complications

Giovanni      Fazio; Giovanni      Ferro; Giuseppe      Barbaro; Kalil      Fattouch; Filippo      Ferrara; Giuseppina      Novo; Salvatore      Novo

doi:10.2174/138161210793563310

Abstract

The foramen ovale, an atrial septal defect, which is essential in the fetal circulation, remains patent through adulthood in approximately 25% of the general population and therefore it represents the most common persistent abnormality of fetal origin. Patent foramen ovale (PFO) allows interatrial right-to-left blood shunting during those periods of the cardiac cycle in which the right atrial pressure exceeds the left one. An increasing number of pathological manifestations of PFO has been recently identified; among these, paradoxical systemic embolism, refractory hypoxemia in patients with right ventricular myocardium infarction or severe pulmonary disease, orthostatic oxygen desaturation in the rare platypnea-orthodeoxia syndrome, neurological decompression illness in divers, high altitude pilots and astronauts, and finally, migraine headache with aura. Nowadays, many techniques allow to detect a PFO. In this study, we investigated each of them, assessing their potential diagnostic role even in comparison with the main features of the other methods.

Keywords: Patent foramen ovale, diagnostic methods, three dimensional echocardiography, Thromboembolic Complications, atrial septal defect, fetal circulation, cardiac cycle, refractory hypoxemia, ventricular myocardium, paradoxical systemic embolism, pulmonary disease, orthostatic oxygen desatura-tion, platypnea-orthodeoxia syndrome, migraine headache, interatrial fetal septa, septum primum, septum secundum, cryptoge-netic, orthostatic oxygen, dyspnea, cryptogenetic strokes, interatrial septum aneurism, cryp-togenetic ictus, microischemia, TRANSTHORACIC ECHOCARDIOGRAPHY, doppler ve-locimetric method, TRANSCRANIC ULTRASONOGRAPHY, transesophageal ecocardiography's one, Valsalva maneuver, CONTRAST ECHOCARDIOGRAPHY, COMPUTED TOMOGRAPHY (TC), NUCLEAR MAGNETIC RESONANCE (NMR)