Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy

Title:Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy

Volume: 12 Issue: 2

Author(s): Frank Spillmann, Sophie Van Linthout and Carsten Tschope

Affiliation:

Keywords: Diabetes mellitus, dysfunction, endothelial dysfunction, glucose metabolism, high-density lipoprotein, remodeling

Abstract: Diabetic cardiopathy includes a specific cardiomyopathy, which occurs in the absence of coronary heart disease and hypertension under diabetes mellitus. Hyperglycemia, hyperinsulinemia, and hyperlipidemia, characteristic metabolic disturbances evident in diabetes mellitus, all three lead to a specific altered cardiac structure and function. Recently, it has been demonstrated that altered HDL, be it low HDL or dysfunctional HDL is not only a consequence of diabetes mellitus, but can also contribute to the development of diabetes mellitus, and therefore also of diabetic cardiomyopathy. This review summarizes how HDL can indirectly affect diabetic cardiomyopathy via their influence on the metabolic triggers hyperglycemia, hyperinsulinemia, and hyperlipidemia, and how they can directly influence the cardiac cellular consequences, typical for diabetic cardiomyopathy, including inflammation, oxidative stress, apoptosis, fibrosis, Ca2+ handling, glucose homeostasis, and endothelial dysfunction.

Cite this article as:

Spillmann Frank, Van Linthout Sophie and Tschope Carsten, Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy, Endocrine, Metabolic & Immune Disorders - Drug Targets 2012; 12 (2) . https://dx.doi.org/10.2174/187153012800493521