Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants

Title:Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants

Volume: 12 Issue: 9

Author(s): Rosaria Gitto, Laura De Luca, Sara De Grazia and Alba Chimirri

Affiliation:

Keywords: AMPA, anticonvulsants, epilepsy, glutamate, glutamate transporters, iGluR, mGluR

Abstract: Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) controlling physiological processes as learning and memory. However, the overactivation of glutamatergic neurotransmission is often related to various CNS chronic and acute diseases (epilepsy, ischaemia, Parkinson, etc.). This review will focus on the chemical structures, mechanism of action and main structure-activity relationships of anticonvulsant agents acting through glutamate neurotransmission.

Cite this article as:

Gitto Rosaria, De Luca Laura, De Grazia Sara and Chimirri Alba, Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants, Current Topics in Medicinal Chemistry 2012; 12 (9) . https://dx.doi.org/10.2174/156802612800229242