Abstract
Bone marrow (BM) holds a pool of stem and progenitor cells whose role is not limited to hematopoiesis. Indeed, growing evidences showed that BM-derived progenitors could contribute to various extents to cardiovascular homeostasis. Notably, diabetic patients experience an intrinsic defect of the progenitor pool, whereas some recent works point directly to an intrinsic defect of the BM, resulting in defective mobilization and impaired functions of progenitors. These defects could have important pathophysiological roles in the development of diabetic complications. An integrated approach, which enhances mobilization of progenitors and improves their functions, could represent a novel method to improve cardiovascular repair by endogenous progenitors. Furthermore, potential clinical trials of cell therapy would gain benefit from stratagems that enhance the number and functions of progenitors prior to transplantation. In this review we discuss the strategies to stimulate the mobilization of progenitors in diabetes and the protocols to improve their functions.
Keywords: Diabetes, progenitors, bone marrow, mobilization
Current Vascular Pharmacology
Title:Strategies for Enhancing Progenitor Cell Mobilization and Function in Diabetes
Volume: 10 Issue: 3
Author(s): Mattia Albiero and Gian P. Fadini
Affiliation:
Keywords: Diabetes, progenitors, bone marrow, mobilization
Abstract: Bone marrow (BM) holds a pool of stem and progenitor cells whose role is not limited to hematopoiesis. Indeed, growing evidences showed that BM-derived progenitors could contribute to various extents to cardiovascular homeostasis. Notably, diabetic patients experience an intrinsic defect of the progenitor pool, whereas some recent works point directly to an intrinsic defect of the BM, resulting in defective mobilization and impaired functions of progenitors. These defects could have important pathophysiological roles in the development of diabetic complications. An integrated approach, which enhances mobilization of progenitors and improves their functions, could represent a novel method to improve cardiovascular repair by endogenous progenitors. Furthermore, potential clinical trials of cell therapy would gain benefit from stratagems that enhance the number and functions of progenitors prior to transplantation. In this review we discuss the strategies to stimulate the mobilization of progenitors in diabetes and the protocols to improve their functions.
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Cite this article as:
Albiero Mattia and P. Fadini Gian, Strategies for Enhancing Progenitor Cell Mobilization and Function in Diabetes, Current Vascular Pharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157016112799959387
DOI https://dx.doi.org/10.2174/157016112799959387 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
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