Abstract
The design of a microfluidic nanoporous reflective interferometric (RIfS) sensor is presented. The key element of the sensor is a highly ordered nanoporous structure of anodic aluminium oxide (AAO) integrated into a microfluidic chip and combined with an optical fibre spectrophotometer and notebook computer. AAO with controlled pore dimensions was prepared by electrochemical anodization of aluminium using 0.3 M oxalic acid at 50V for 40 minutes. The performance of the microfluidic RIfS for sensing of surface binding reaction of alkanethiols (mercapto undecanoic acid) on gold is evaluated showing excellent sensitivity. The results show potential for development and application of interferometric label-free biosensing elements for a wide range of biomedical applications.
Keywords: Reflective interferometric spectroscopy, nanoporous alumina, microchip interference sensor, Fabry-Perot fringes, micro-chip devices, Refractive index, REFLACTIVE INTERFEROMETRIC, Fabrications, RIfS, AAO Sensor
Micro and Nanosystems
Title: Bioinspired Microchip Nanoporous Interferometric Sensor for Sensing and Biosensing Applications
Volume: 3 Issue: 4
Author(s): Tushar Kumeria, Luke Parkinson and Dusan Losic
Affiliation:
Keywords: Reflective interferometric spectroscopy, nanoporous alumina, microchip interference sensor, Fabry-Perot fringes, micro-chip devices, Refractive index, REFLACTIVE INTERFEROMETRIC, Fabrications, RIfS, AAO Sensor
Abstract: The design of a microfluidic nanoporous reflective interferometric (RIfS) sensor is presented. The key element of the sensor is a highly ordered nanoporous structure of anodic aluminium oxide (AAO) integrated into a microfluidic chip and combined with an optical fibre spectrophotometer and notebook computer. AAO with controlled pore dimensions was prepared by electrochemical anodization of aluminium using 0.3 M oxalic acid at 50V for 40 minutes. The performance of the microfluidic RIfS for sensing of surface binding reaction of alkanethiols (mercapto undecanoic acid) on gold is evaluated showing excellent sensitivity. The results show potential for development and application of interferometric label-free biosensing elements for a wide range of biomedical applications.
Export Options
About this article
Cite this article as:
Kumeria Tushar, Parkinson Luke and Losic Dusan, Bioinspired Microchip Nanoporous Interferometric Sensor for Sensing and Biosensing Applications, Micro and Nanosystems 2011; 3 (4) . https://dx.doi.org/10.2174/1876402911103040290
DOI https://dx.doi.org/10.2174/1876402911103040290 |
Print ISSN 1876-4029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1876-4037 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases
Current Medicinal Chemistry Genipin Inhibits the Induction of Inducible Nitric Oxide Synthase Through the Inhibition of NF-κB Activation in Rat Hepatocytes
Drug Metabolism Letters The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations
Current Medicinal Chemistry Potential of Selected Indian Herbs for COVID-19
Current Traditional Medicine Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design
Current Topics in Medicinal Chemistry Novel Stereoselective Oximes: Their Synthesis and Anti-leishmanials Evaluation
Current Bioactive Compounds SAXS Studies of Human Protein HC (α1-Microglobulin)
Protein & Peptide Letters Novel Carriers for Controlled Site Specific Delivery of Anti-Inflammatory Agents
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Comparative Approach of the de novo Fatty Acid Synthesis (Lipogenesis) between Ruminant and Non Ruminant Mammalian Species: From Biochemical Level to the Main Regulatory Lipogenic Genes
Current Genomics The Association Between the Chronic Use of Non-Steroidal Anti- Inflammatory Drugs and Oxidative and Inflammatory Markers in the Elderly
Inflammation & Allergy - Drug Targets (Discontinued) Withdrawal Notice: Synergistic Effect of Myricetin and Phenolic Acid Derivatives on the Reversal of Dengue Fever Related Thrombocytopenia and its Pharmacokinetics study in Plasma by using HPLC and UPLC-Q-TOF
Current Drug Metabolism Fungal Laccases and their Biotechnological Significances in the Current Perspective: A Review
Current Organic Chemistry Metabolomics of Medicinal Plants: The Importance of Multivariate Analysis of Analytical Chemistry Data
Current Computer-Aided Drug Design Proteomics and Epigenetic Mechanisms in Stem Cells
Current Proteomics The Emerging Pharmacology of TRPM8 Channels: Hidden Therapeutic Potential Underneath a Cold Surface
Current Pharmaceutical Biotechnology The Cytotoxic and Immunomodulatory Effects of Titanium Dioxide Nanoparticles and <i>Sargassum oligocystum</i> on <i>Toxoplasma gondii In Vitro</i> and <i>In Vivo</i>
Anti-Infective Agents The Effects of Maternally Administered Methadone, Buprenorphine and Naltrexone on Offspring: Review of Human and Animal Data
Current Neuropharmacology SAR and QSAR of the Antioxidant Activity of Flavonoids
Current Medicinal Chemistry Subcellular Imaging and Diagnosis of Cancer using Engineered Nanoparticles
Current Pharmaceutical Design Near-infrared Light Activatable Multimodal Gold Nanostructures Platform: An Emerging Paradigm for Cancer Therapy
Current Cancer Drug Targets