Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives

Title: Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives

Volume: 10 Issue: 1

Author(s): Noopur Srivastava, K. S. Anil Kumar, Sudhir Sinha, Ranjana Srivastava and D. K. Dikshit

Affiliation:

Keywords: BACTEC, Coumarin, MDR tuberculosis, pechman condensation, triarylmethanes, tuberculosis, BCG, Benzofurans, ANTI-TUBERCULAR ACTIVITY, DMAP

Abstract: Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.

Cite this article as:

Srivastava Noopur, Anil Kumar K. S., Sinha Sudhir, Srivastava Ranjana and Dikshit D. K., Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives, Anti-Infective Agents 2012; 10 (1) . https://dx.doi.org/10.2174/2211362611201010006