Patient-Specific Alpha-Particle Dosimetry

Stig      Palm; Jorgen      Elgqvist; Lars      Jacobsson

doi:10.2174/1874471011104040329

Abstract

Alpha-particle therapy has received increased attention during the last few years because of the development of new targeting constructs and new labeling techniques and the availability of suitable α-particle – emitting radionuclides. This work provides an overview of methods that have been used in clinical trials in estimating the absorbed dose to tumors and healthy tissue in patients following such α-particle therapy. Similarities and differences compared to conventional therapies using β¯-particle emitters are presented. The specific challenges of establishing accurate dosimetry for α- particles in the individual patient are also discussed, as is the effect that improved patient-specific dosimetry might have on the overall efficacy of this type of therapy.

Keywords: Alpha-particles, clinical trials, dosimetry, radionuclide therapy, regulators, (MTA, PATIENT PHARMACOKINETICS, PATIENT DOSIMETRY, Gamma Counters and Probes, Quantitative Imaging