Patient-Specific Alpha-Particle Dosimetry

Title: Patient-Specific Alpha-Particle Dosimetry

Volume: 4 Issue: 4

Author(s): Stig Palm, Jorgen Elgqvist and Lars Jacobsson

Affiliation:

Keywords: Alpha-particles, clinical trials, dosimetry, radionuclide therapy, regulators, (MTA, PATIENT PHARMACOKINETICS, PATIENT DOSIMETRY, Gamma Counters and Probes, Quantitative Imaging

Abstract: Alpha-particle therapy has received increased attention during the last few years because of the development of new targeting constructs and new labeling techniques and the availability of suitable α-particle – emitting radionuclides. This work provides an overview of methods that have been used in clinical trials in estimating the absorbed dose to tumors and healthy tissue in patients following such α-particle therapy. Similarities and differences compared to conventional therapies using β¯-particle emitters are presented. The specific challenges of establishing accurate dosimetry for α- particles in the individual patient are also discussed, as is the effect that improved patient-specific dosimetry might have on the overall efficacy of this type of therapy.

Cite this article as:

Palm Stig, Elgqvist Jorgen and Jacobsson Lars, Patient-Specific Alpha-Particle Dosimetry, Current Radiopharmaceuticals 2011; 4 (4) . https://dx.doi.org/10.2174/1874471011104040329