Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Title: Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Volume: 3 Issue: 2

Author(s): Loren M. Berry, Lance Wollenberg and Zhiyang Zhao

Affiliation:

Keywords: Carboxylesterase, cholinesterase, paraoxonase, species difference

Abstract: Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.

Cite this article as:

Berry M. Loren, Wollenberg Lance and Zhao Zhiyang, Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans, Drug Metabolism Letters 2009; 3 (2) . https://dx.doi.org/10.2174/187231209788654081