Abstract
Baculoviruses are lethal pathogens of insects, predominantly of the order Lepidoptera. These viruses have a biphasic life cycle, which greatly facilitates their use for biotechnological applications. They were exploited initially as biocontrol agents, and then engineered as protein expression vectors. The baculovirus expression vector system (BEVS) is now widely used for recombinant protein production. More recently they have become a popular choice for development as gene delivery and expression vectors in mammalian cells. This article reviews some of the major developments and patents relating to baculoviruses since their initial use as an expression tool and investigates current technologies alleviating bottlenecks in recombinant gene expression in insect cells.
Keywords: Baculovirus, budded virus, bacmid, high throughput and recombinant protein expression
Recent Patents on Biotechnology
Title: Baculovirus Expression Systems for Recombinant Protein Production in Insect Cells
Volume: 3 Issue: 1
Author(s): Richard B. Hitchman, Robert D. Possee and Linda A. King
Affiliation:
Keywords: Baculovirus, budded virus, bacmid, high throughput and recombinant protein expression
Abstract: Baculoviruses are lethal pathogens of insects, predominantly of the order Lepidoptera. These viruses have a biphasic life cycle, which greatly facilitates their use for biotechnological applications. They were exploited initially as biocontrol agents, and then engineered as protein expression vectors. The baculovirus expression vector system (BEVS) is now widely used for recombinant protein production. More recently they have become a popular choice for development as gene delivery and expression vectors in mammalian cells. This article reviews some of the major developments and patents relating to baculoviruses since their initial use as an expression tool and investigates current technologies alleviating bottlenecks in recombinant gene expression in insect cells.
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Cite this article as:
Hitchman B. Richard, Possee D. Robert and King A. Linda, Baculovirus Expression Systems for Recombinant Protein Production in Insect Cells, Recent Patents on Biotechnology 2009; 3 (1) . https://dx.doi.org/10.2174/187220809787172669
DOI https://dx.doi.org/10.2174/187220809787172669 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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