Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes

Title: Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes

Volume: 2 Issue: 1

Author(s): Christa Kneip, Rolf Terlinden, Horst Beier and Genfu Chen

Affiliation:

Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation

Abstract: The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.

Cite this article as:

Kneip Christa, Terlinden Rolf, Beier Horst and Chen Genfu, Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes, Drug Metabolism Letters 2008; 2 (1) . https://dx.doi.org/10.2174/187231208783478434