Identification of a Novel Inhibitor of the NF-κB Pathway

Title: Identification of a Novel Inhibitor of the NF-κB Pathway

Volume: 1 Issue: 1

Author(s): A. Misra-press, M. McMillan, E. Cudaback, M. Qabar, F. Ruan, M. Nguyen, T. Vaisar, H. Nakanishi and M. Kahn

Affiliation:

Keywords: inhibitor, cytotoxicity

Abstract: NF-κB1 plays a central role in regulating genes involved in inflammatory responses, and its recently described role in oncogenesis reemphasizes its importance as a critical mediator of cellular function. We describe herein a novel inhibitor (MOL-294) of NF-κB driven transcription that does not inhibit the proteasome complex, does not inhibit IκB2 phosphorylation, and does not significantly inhibit nuclear translocation of the p65 / RelA subunit of NF-κB. We have identified thioredoxin, a cellular redox protein, which has previously been implicated in the regulation of NF-κB driven transcription, as one of the intracellular targets of MOL-294. The identification of a low molecular weight inhibitor of this type of redox protein represents a novel mechanism of inhibiting the NF-κB signaling pathway.

Cite this article as:

Misra-press A., McMillan M., Cudaback E., Qabar M., Ruan F., Nguyen M., Vaisar T., Nakanishi H. and Kahn M., Identification of a Novel Inhibitor of the NF-κB Pathway, Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents 2002; 1 (1) . https://dx.doi.org/10.2174/1568014024606566

DOI https://dx.doi.org/10.2174/1568014024606566	Print ISSN 1568-0142
Publisher Name Bentham Science Publisher	Online ISSN 1875-6131