A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms

Title: A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms

Volume: 4 Issue: 5

Author(s): Giovanni Capranico

Affiliation:

Keywords: regulation mechanisms, drug discovery, antitumor activity, molecular target, chemoprevention, dna topoisomerase, rational approach

Abstract: The cancer mortality remains high, although progress has been attained by chemotherapy and other therapeutic strategies. Effective cancer prevention interventions would markedly reduce the cancer mortality burden, thus chemoprevention and chemotherapy must be seen as complementary approaches to fight human cancers. Nevertheless, our understanding of drug mechanisms of action is rather limited as we do not know the behaviour of highly-complex regulatory networks of the cell and how they respond to a particular small molecule. Similarly, that limits a truly rational approach to drug discovery and identification of good molecular targets. Until we get deeper insights into fundamental mechanisms of cellular functions, the approach to drug design and discovery will remain empirical.

Cite this article as:

Capranico Giovanni, A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms, Current Medicinal Chemistry - Anti-Cancer Agents 2004; 4 (5) . https://dx.doi.org/10.2174/1568011043352821