Synthesis and in vitro Anti-tumor Activity of Some New Sebacoyl Chloride Based Heterocycles

Title:Synthesis and in vitro Anti-tumor Activity of Some New Sebacoyl Chloride Based Heterocycles

Volume: 14 Issue: 2

Author(s): Islam H. El Azab*Nadia A.A. Elkanzi

Affiliation:

• Chemistry Department, Faculty of Science, Aswan University, Aswan, P.O. box 81528, Aswan,Egypt

Keywords: Sebacoyl chloride, acid chloride, decanedihydrazide, azole, N-heterocycles, anti-tumour activity., Sebacoyl chloride, acid chloride, decanedihydrazide, azole, N-heterocycles, anti-tumour activity.

Abstract: Background: N-Heterocycles are of special interest because, many natural and synthetic bioactive compounds are found to be N-containing heterocycles and they constitute an important class of pharmacophores in medicinal chemistry. Recently, 1,2,3-triazoles have been found to possess a vast range of vital applications in the agrochemical, pharmaceutical, and materials field. In addition, various compounds of the 1,2,3-triazole family have shown a broad spectrum of biological properties such as antibacterial, and anti-HIV activity. 1,3,4- Oxadiazoles are important oxygen and nitrogen containing heterocyclic compounds, they possess desirable electronic and charge-transport properties.

Methods: Two mammalian cell lines were grown in RPMI-1640 medium, supplemented with 10% heat inactivated FBS, 50 units/mL of penicillin and 50 g/mL of streptomycin and maintained at 37 °C in a humidified atmosphere containing 5% CO2. The cells were maintained as “monolayer culture” by serial sub-culturing. Preliminary cytotoxicity was performed using SRB method.

Results: Sebacoyl chloride and decanedihydrazide dihydrochloride are utilized as versatile building blocks to annulate a series of novel azole and/ or azine systems. The in vitro anti-tumor activities of the synthesized compounds were evaluated against human breast cancer cell line (MCF-7) and human cervical cancer cell line (HeLa). The obtained data indicated that the majority of the tested compounds possess significant anti-tumor activities against the tested tumor cell lines.

Conclusion: Sebacoyl chloride, decanedihydrazide dihydrochloride and N-nucleophiles are useful precursors for the synthesis of different functionalized N- heterocycles. The cytotoxic study revealed that the majority of the tested compounds possess significant anti-tumor activity towards the tested tumor cell lines.

Cite this article as:

Azab H. El Islam*, Elkanzi A.A. Nadia, Synthesis and in vitro Anti-tumor Activity of Some New Sebacoyl Chloride Based Heterocycles, Current Organic Synthesis 2017; 14 (2) . https://dx.doi.org/10.2174/1570179413666161008200206

DOI https://dx.doi.org/10.2174/1570179413666161008200206	Print ISSN 1570-1794
Publisher Name Bentham Science Publisher	Online ISSN 1875-6271