Cytotoxic Activity of Polysubstituted 7-chloro-4-quinolinylhydrazone Derivatives

Title: Cytotoxic Activity of Polysubstituted 7-chloro-4-quinolinylhydrazone Derivatives

Volume: 9 Issue: 3

Author(s): Raquel Carvalho Montenegro, Leticia Veras Lotufo, Manoel Odorico de Moraes, Claudia do O Pessoa, Felipe Augusto Rocha Rodrigues, Marcelle de Lima Ferreira Bispo, Bruna Abreu Freire, Carlos Roland Kaiser and Marcus Vinicius Nora de Souza

Affiliation:

Keywords: Antitumor activity, Chloroquine, Drugs, Hydrazones, Quinoline, World Health Organization (WHO), quinoline derivatives, CQ, synthetic route, benzene ring, Buchi apparatus, Chemical shifts, Waters mass spectrometer, Cell Membrane Disruption, Cytotoxicity

Abstract: A series of fourteen polysubstituted 7-chloro-4-quinolinylhydrazone derivatives (3a-n) has been synthesized and evaluated for their activity against four cancer cell lines. Among them, compounds 3a, 3c, 3h, 3i, 3j and 3n showed good cytotoxicity (with IC50 ranging from 0.7483 to 5.572 μg/mL). In general, we observed that the presence of methoxy groups on benzene ring plays an important role in the anticancer activity of this series, especially when they are located in 3,4 (3h) or 3,4,5 (3j) positions. These derivatives could be considered a relevant finding towards the rational design of new leads for antitumoral agents.

Cite this article as:

Carvalho Montenegro Raquel, Veras Lotufo Leticia, Odorico de Moraes Manoel, do O Pessoa Claudia, Augusto Rocha Rodrigues Felipe, de Lima Ferreira Bispo Marcelle, Abreu Freire Bruna, Roland Kaiser Carlos and Vinicius Nora de Souza Marcus, Cytotoxic Activity of Polysubstituted 7-chloro-4-quinolinylhydrazone Derivatives, Letters in Drug Design & Discovery 2012; 9 (3) . https://dx.doi.org/10.2174/157018012799129837

DOI https://dx.doi.org/10.2174/157018012799129837	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X