Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions

Title: Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions

Volume: 16 Issue: 7

Author(s): Laura Zaccaro, Annarita del Gatto, Carlo Pedone and Michele Saviano

Affiliation:

Keywords: CCK, somatostatin, integrin, structure-activity relationships, tumour diseases

Abstract: The use of peptides as targeting tools has been validated in different applications. In particular radiolabelled peptides with adequate stability, receptor-binding properties and biokinetic behaviour have been investigated as an important class of radiopharmaceuticals for cancer pathology imaging and therapy. This review focuses on recent progress in design and synthetic modifications of small biologically active peptides used in diagnosis and therapy. In particular, we report the current development and optimization of suitable peptides for targeting three relevant biological receptors (CCK, somatostatin, and integrin receptors) involved in specific tumour diseases.

Cite this article as:

Zaccaro Laura, Gatto del Annarita, Pedone Carlo and Saviano Michele, Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions, Current Medicinal Chemistry 2009; 16 (7) . https://dx.doi.org/10.2174/092986709787549307