Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages

Title: Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages

Volume: 9 Issue: 2

Author(s): Anna M. Varizhuk, Svetlana V. Kochetkova, Alexander U. Fedotov, Natalia A. Kolganova, Edward N. Timofeev and Vladimir L. Florentiev

Affiliation:

Keywords: Analogs, hybridization, oligonucleotides, peptide internucleotide linkages, synthesis, thermal stability, duplexes, triplexes, epimerization, dichloromethane

Abstract: Oligonucleotide analogs with L- and D-lysine residues incorporated in internucleotide linkages were synthesized and their affinity toward complementary DNA was studied. Stability of the duplexes formed by the modified oligonucleotides and their wild-type complements appeared to be close to that of the isosequential unmodified duplex, oligonucleotides carrying D-lysine residues forming generally more stable duplexes than L-lysine derivatives.

Cite this article as:

M. Varizhuk Anna, V. Kochetkova Svetlana, U. Fedotov Alexander, A. Kolganova Natalia, N. Timofeev Edward and L. Florentiev Vladimir, Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages, Letters in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157017812800221799