Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor

Title: Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor

Volume: 8 Issue: 9

Author(s): Jing Li, Huan Li and Lei Zhang

Affiliation:

Keywords: Crystal structure, HMG-CoA reductase, hydrogenation, pravastatin, 4, 5, 6, 7-tetrahydropravastatin, Tetrahydropravastatin, Staphylococcus aureus, SARs, HMG-CoA, CHD, Atherosclerotic, LDL-C, rhabdomoylsis, Elemental analyses

Abstract: 4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.

Cite this article as:

Li Jing, Li Huan and Zhang Lei, Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor, Letters in Drug Design & Discovery 2011; 8 (9) . https://dx.doi.org/10.2174/157018011797200876

DOI https://dx.doi.org/10.2174/157018011797200876	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X