Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage

Title:Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage

Volume: 10 Issue: 3

Author(s): Masahiro Uemura, Yukiko Kasahara, Kazuyuki Nagatsuka and Akihiko Taguchi

Affiliation:

Keywords: Angiogenesis, neurogenesis, stroke, neural stem cells, CD34-positive cells

Abstract: Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.

Cite this article as:

Uemura Masahiro, Kasahara Yukiko, Nagatsuka Kazuyuki and Taguchi Akihiko, Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage, Current Vascular Pharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157016112799959369