Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines

Title: Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines

Volume: 8 Issue: 8

Author(s): Chunyan Xu, Chuanjie Cheng, Hongtao Liu and Bo Liu

Affiliation:

Keywords: 2-methoxy-4-substituted pyrimidine, azaheterocycles, chemoselective synthesis, diazotization, hydrolysis, antibiotics, vitamins, alkaloids, heterocyclic pyrimidines, catalysis

Abstract: Three 2-methoxy-4-substituted pyrimidine compounds were chemoselectively synthesized by diazotization, using 2,4-dichloropyrimidine as the starting material. In nonaqueous diazotization reaction system, halo-substituted 6 and 7 were efficiently prepared, and in aqueous medium, hydrolysis product 8 was afforded.

Cite this article as:

Xu Chunyan, Cheng Chuanjie, Liu Hongtao and Liu Bo, Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines, Letters in Organic Chemistry 2011; 8 (8) . https://dx.doi.org/10.2174/157017811797249371