Synthesis and Biological Properties of Dihydro-Oxadiazine-Based Heterocyclic Derivatives

S.      Ke; X.      Cao; Y.      Liang; K.      Wang; Z.      Yang

doi:10.2174/138955711796268769

Abstract

Dihydro-oxadiazine and its derivatives have been demonstrated to be important heterocyclic scaffold platform with bioactive diversity, which present wide activities such as cardiovascular, antitumor, antibacterial, antimicrobial, acricidal, insecticidal, plant-growth regulating, chitin biosynthesis inhibitors and monoamine oxidase inhibition. Versatile features of dihydro-oxadiazine heterocycles have emerged, so the aim of the present paper was to review the recent advances of dihydro-oxadiazine-based heterocyclic derivatives mainly including synthesis and biological activities.

Keywords: Dihydro-oxadiazine, heterocycle, synthesis, biological activity, heterocyclic scaffold, cardiovascular, antitumor, antibacterial, antimicrobial, acricidal, insecticidal, plant-growth regulating, chitin biosynthesis, monoamine oxidase