Evolving Concepts Concerning Cardiac β-Adrenoceptor Function in Heart Failure

Title: Evolving Concepts Concerning Cardiac β-Adrenoceptor Function in Heart Failure

Volume: 16 Issue: 37

Author(s): J. Black and D. Fitzgerald

Affiliation:

Keywords: Selective adrenoceptor blockade, heart failure, MAP/ERK activation

Abstract: This review describes the clinical application of β-adrenergic blocking drugs over time in patients with congestive heart failure. The different pharmacological properties of these drugs in relation to clinical outcomes raise questions as to their optimal desirable profile based on studies showing the undesirable effects of excessive β2-AR activation. The rationale for the use of selective β2-AR antagonists in heart failure is discussed.

Cite this article as:

Black J. and Fitzgerald D., Evolving Concepts Concerning Cardiac β-Adrenoceptor Function in Heart Failure, Current Pharmaceutical Design 2010; 16 (37) . https://dx.doi.org/10.2174/138161210794519200