Synthesis of (±) Travoprost and its Analogs

Title: Synthesis of (±) Travoprost and its Analogs

Volume: 8 Issue: 4

Author(s): Harikrishna Mudduluru, Rama M. Hindupur, Pramod K. Dubey, Shankar Madhavaram, Lakshmikumar Tatini and Gottumukkala V. Subbaraju

Affiliation:

Keywords: Prostaglandins, antiglaucoma, (±) travoprost, Phosphonate, n-BuLi, dimethyl, methane, dimethoxyethane, alkylation

Abstract: A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner – Wadsworth – Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.

Cite this article as:

Mudduluru Harikrishna, M. Hindupur Rama, K. Dubey Pramod, Madhavaram Shankar, Tatini Lakshmikumar and V. Subbaraju Gottumukkala, Synthesis of (±) Travoprost and its Analogs, Letters in Organic Chemistry 2011; 8 (4) . https://dx.doi.org/10.2174/157017811795371485