Abstract
Background & Objective: Multiple classes of natural products, such as antiandrogens or steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases. This paper aims to review current knowledge on these substances and their possible relationship with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive review of the neurochemical mechanisms of these substances in the central nervous system of humans and animal models is yet to be undertaken in the literature, particularly regarding their importance and increasing use.
Conclusion: Androgen receptor antagonists act in a different way that may underlie the benefits of natural products, with the expectation that in adults, neurological disorders would respond to natural antiandrogens. We hope that this work would provide valuable insight into the protective and therapeutic roles for natural antiandrogens and steroids in common neurological disorders.
Keywords: Androgens, antagonist, CNS, neurological disorders, neuroprotectors, steroids.
Graphical Abstract
CNS & Neurological Disorders - Drug Targets
Title:Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders
Volume: 16 Issue: 7
Author(s): David Calderon Guzman, Hugo Juarez Olguin*, Ernestina Hernandez Garcia, Monica Punzo Soto, Mayra Santillan Garcia and Gerardo Barragan Mejia
Affiliation:
- Laboratory of Pharmacology, National Institute of Pediatrics, Av. Iman No.1, 3rd piso, Colonia Cuicuilco. CP. 04530, Mexico City,Mexico
Keywords: Androgens, antagonist, CNS, neurological disorders, neuroprotectors, steroids.
Abstract: Background & Objective: Multiple classes of natural products, such as antiandrogens or steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases. This paper aims to review current knowledge on these substances and their possible relationship with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive review of the neurochemical mechanisms of these substances in the central nervous system of humans and animal models is yet to be undertaken in the literature, particularly regarding their importance and increasing use.
Conclusion: Androgen receptor antagonists act in a different way that may underlie the benefits of natural products, with the expectation that in adults, neurological disorders would respond to natural antiandrogens. We hope that this work would provide valuable insight into the protective and therapeutic roles for natural antiandrogens and steroids in common neurological disorders.
Export Options
About this article
Cite this article as:
Guzman Calderon David , Olguin Juarez Hugo *, Garcia Hernandez Ernestina , Soto Punzo Monica , Garcia Santillan Mayra and Mejia Barragan Gerardo , Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders, CNS & Neurological Disorders - Drug Targets 2017; 16 (7) . https://dx.doi.org/10.2174/1871527316666170714121654
DOI https://dx.doi.org/10.2174/1871527316666170714121654 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ghetto Poverty and Pollution in Egypt: A Deadly Threat for Western Countries Caused by New and Infectious Mutants. A Cultural, Social and Microbiological Synopsis
Inflammation & Allergy - Drug Targets (Discontinued) Pharmacology of Appetite Suppression: Implication for the Treatment of Obesity
Current Drug Targets Oil-based Formulation as a Sustained-Released Injection for a Novel Synthetic Peptide
Current Pharmaceutical Biotechnology Post-Translational Protein Modifications of Rare and Unconventional Types: Implications in Functions and Diseases
Current Medicinal Chemistry siRNA Delivery Using Nanocarriers – An Efficient Tool for Gene Silencing
Current Gene Therapy A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment
Current Drug Targets Synthesis, Biochemical Evaluation and Rationalisation of a Series of 3,5- Dibromo Derivatives of 4-Hydroxyphenyl Ketone-Based Compounds as Probes of the Active Site of Type 3 of 17β-Hydroxysteroid Dehydrogenase (17β-HSD3) and the Role of Hydrogen Bonding Interaction in the Inhibition of 17β-HSD3
Letters in Drug Design & Discovery Prognostic and Predictive Molecular Markers in Cutaneous Malignant Melanoma: The First Step Toward Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Pro-apoptotic Activity of BH3-only Proteins and BH3 Mimetics: from Theory to Potential Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Anticancer Activity and DNA Binding of 4-Alkylenediamines Modified Naphthalimide Derivatives
Letters in Drug Design & Discovery Recent Advances and Developments in Treatment Strategies Against Pancreatic Cancer
Current Clinical Pharmacology Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
Current Drug Safety Smart Polymer Based Delivery Systems for Peptides and Proteins
Recent Patents on Drug Delivery & Formulation Preface: The Inaugural Issue of Clinical Immunology Endocrine Metabolic Drugs
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Regulators of Stem Cells Proliferation in Tissue Regeneration
Current Stem Cell Research & Therapy Apoptosis Induction by Erucylphosphohomocholine via the 18 kDa Mitochondrial Translocator Protein: Implications for Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Lipid-based Nano-phytomedicines for Disease Treatment and Theranostic Applications
Current Nanomedicine Chemokines and Breast Cancer: A Gateway to Revolutionary Targeted Cancer Treatments?
Current Medicinal Chemistry Neuropeptide - Adipose Tissue Communication and Intestinal Pathophysiology
Current Pharmaceutical Design Chromogranin A and the Endothelial Barrier Function
Current Medicinal Chemistry