Synthesis of N1- and N8-(γ -L-Glutamyl)spermidines and (γ -L-Glutamyl) putrescine

Title: Synthesis of N1- and N8-(γ -L-Glutamyl)spermidines and (γ -L-Glutamyl) putrescine

Volume: 8 Issue: 1

Author(s): Kazuya Toho, Naoki Abe, Teiko Yamada, Yoshifumi Ito, Hiroyuki Konno, Shigefumi Kuwahara and Hiromasa Kiyota

Affiliation:

Keywords: glutamylspermidine, glutamylputrescine, Pseudomonas aeruginosa, polyamine biosynthesis, polyamine glutamyl transferase

Abstract: (γ-L-Glutamyl)putrescine and N1- and N8-(γ-L-glutamyl)spermidines, possible regioisomeric products of the polyamine glutamyl transferase of bacteria such as Escherichia coli and Pseudomonas aeruginosa, were synthesized from N-Boc-protected putrescine and 1,3-propanediamine.

Cite this article as:

Toho Kazuya, Abe Naoki, Yamada Teiko, Ito Yoshifumi, Konno Hiroyuki, Kuwahara Shigefumi and Kiyota Hiromasa, Synthesis of N1- and N8-(γ -L-Glutamyl)spermidines and (γ -L-Glutamyl) putrescine, Letters in Organic Chemistry 2011; 8 (1) . https://dx.doi.org/10.2174/157017811794557813