Abstract
The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.
Keywords: Melanin-concentrating hormone, melanin-concentrating hormone receptor, antagonist, obesity
Current Topics in Medicinal Chemistry
Title: Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1
Volume: 7 Issue: 15
Author(s): Maria A. Bednarek
Affiliation:
Keywords: Melanin-concentrating hormone, melanin-concentrating hormone receptor, antagonist, obesity
Abstract: The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.
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Cite this article as:
Bednarek A. Maria, Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1, Current Topics in Medicinal Chemistry 2007; 7 (15) . https://dx.doi.org/10.2174/156802607782194734
DOI https://dx.doi.org/10.2174/156802607782194734 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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